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Gut Microbes. 2022 Jan-Dec;14(1):1997294. doi: 10.1080/19490976.2021.1997294.

The ancestral stringent response potentiator, DksA has been adapted throughout .

Gut microbes

Helit Cohen, Boaz Adani, Emiliano Cohen, Bar Piscon, Shalhevet Azriel, Prerak Desai, Heike Bähre, Michael McClelland, Galia Rahav, Ohad Gal-Mor

Affiliations

  1. Sheba Medical Center, The Infectious Diseases Research Laboratory, Tel-Hashomer, Israel.
  2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  3. Department of Clinical Microbiology and Immunology, Tel Aviv University, Tel Aviv, Israel.
  4. Janssen Research & Development, LLC, Raritan, New Jersey, USA.
  5. Department of Microbiology and Molecular Genetics, University of California, Irvine, California, USA.
  6. Hannover Medical School, Research Core Unit Metabolomics, Hannover, Germany.

PMID: 34923900 DOI: 10.1080/19490976.2021.1997294

Abstract

DksA is a conserved RNA polymerase-binding protein known to play a key role in the stringent response of proteobacteria species, including many gastrointestinal pathogens. Here, we used RNA-sequencing of

Keywords: DksA; HGT; RNA-Seq; SPIs; Salmonella; enteric pathogens; pathogenicity; regulation; virulence

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