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Rahman FA, Quadrilatero J. Emerging role of mitophagy in myoblast differentiation and skeletal muscle remodeling. Semin Cell Dev Biol. 2021;doi: 10.1016/j.semcdb.2021.11.026.
Rahman, F. A., & Quadrilatero, J. (2021). Emerging role of mitophagy in myoblast differentiation and skeletal muscle remodeling. Seminars in cell & developmental biology, . https://doi.org/10.1016/j.semcdb.2021.11.026
Rahman, Fasih Ahmad, and Quadrilatero, Joe. "Emerging role of mitophagy in myoblast differentiation and skeletal muscle remodeling." Seminars in cell & developmental biology vol. (2021). doi: https://doi.org/10.1016/j.semcdb.2021.11.026
Rahman FA, Quadrilatero J. Emerging role of mitophagy in myoblast differentiation and skeletal muscle remodeling. Semin Cell Dev Biol. 2021 Dec 16; doi: 10.1016/j.semcdb.2021.11.026. Epub 2021 Dec 16. PMID: 34924331.
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Semin Cell Dev Biol. 2021 Dec 16; doi: 10.1016/j.semcdb.2021.11.026. Epub 2021 Dec 16.

Emerging role of mitophagy in myoblast differentiation and skeletal muscle remodeling.

Seminars in cell & developmental biology

Fasih Ahmad Rahman, Joe Quadrilatero

Affiliations

  1. Department of Kinesiology & Health Sciences, University of Waterloo, Waterloo, ON, Canada.
  2. Department of Kinesiology & Health Sciences, University of Waterloo, Waterloo, ON, Canada. Electronic address: [email protected].

PMID: 34924331 DOI: 10.1016/j.semcdb.2021.11.026

Abstract

Mitochondrial turnover in the form of mitophagy is emerging as a central process in maintaining cellular function. The degradation of damaged mitochondria through mitophagy is particularly important in cells/tissues that exhibit high energy demands. Skeletal muscle is one such tissue that requires precise turnover of mitochondria in several conditions in order to optimize energy production and prevent bioenergetic crisis. For instance, the formation of skeletal muscle (i.e., myogenesis) is accompanied by robust turnover of low-functioning mitochondria to eventually allow the formation of high-functioning mitochondria. In mature skeletal muscle, alterations in mitophagy-related signaling occur during exercise, aging, and various disease states. Nonetheless, several questions regarding the direct role of mitophagy in various skeletal muscle conditions remain unknown. Furthermore, given the heterogenous nature of skeletal muscle with respect to various cellular and molecular properties, and the plasticity in these properties in various conditions, the involvement and characterization of mitophagy requires more careful consideration in this tissue. Therefore, this review will highlight the known mechanisms of mitophagy in skeletal muscle, and discuss their involvement during myogenesis and various skeletal muscle conditions. This review also provides important considerations for the accurate measurement of mitophagy and interpretation of data in skeletal muscle.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Aging; Atrophy; Autophagy; Cancer; Differentiation; Fiber type; Mitochondria; Mitochondrial network; Mitophagy; Myoblasts; Myogenesis; Regeneration; Remodeling; Skeletal muscle

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