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Nichols TA, Nicholson EM, Liu Y, et al. Detection of two dissimilar chronic wasting disease isolates in two captive Rocky Mountain elk (. Prion. 2021;15(1):207-215doi: 10.1080/19336896.2021.1982333.
Nichols, T. A., Nicholson, E. M., Liu, Y., Tao, W., Spraker, T. R., Lavelle, M., Fischer, J., Kong, Q., & VerCauteren, K. C. (2021). Detection of two dissimilar chronic wasting disease isolates in two captive Rocky Mountain elk (. Prion, 15(1), 207-215. https://doi.org/10.1080/19336896.2021.1982333
Nichols, Tracy A, et al. "Detection of two dissimilar chronic wasting disease isolates in two captive Rocky Mountain elk (." Prion vol. 15,1 (2021): 207-215. doi: https://doi.org/10.1080/19336896.2021.1982333
Nichols TA, Nicholson EM, Liu Y, Tao W, Spraker TR, Lavelle M, Fischer J, Kong Q, VerCauteren KC. Detection of two dissimilar chronic wasting disease isolates in two captive Rocky Mountain elk (. Prion. 2021 Dec;15(1):207-215. doi: 10.1080/19336896.2021.1982333. PMID: 34913829.
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Prion. 2021 Dec;15(1):207-215. doi: 10.1080/19336896.2021.1982333.

Detection of two dissimilar chronic wasting disease isolates in two captive Rocky Mountain elk (.

Prion

Tracy A Nichols, Eric M Nicholson, Yihui Liu, Wanyun Tao, Terry R Spraker, Michael Lavelle, Justin Fischer, Qingzhong Kong, Kurt C VerCauteren

Affiliations

  1. Veterinary Services Cervid Health Program, United States Department of Agriculture, Animal and Plant Health Inspection Service, Fort Collins, Colorado, USA.
  2. Us Department of Agriculture, Agricultural Research Service, Ames, Iowa, USA.
  3. Departments of Pathology, Neurology, National Center for Regenerative Medicine, and National Prion Disease Pathology Surveillance Center, Case Western Reserve University, Cleveland, Ohio, USA.
  4. Prion Research Center and the Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Prion Research Center, Fort Collins, Colorado, USA.
  5. Wildlife Services National Wildlife Research Center, United States Department of Agriculture, Animal and Plant Health Inspection Service, Fort Collins, Colorado, USA.

PMID: 34913829 DOI: 10.1080/19336896.2021.1982333

Abstract

Chronic wasting disease (CWD) continues to spread in both wild and captive cervid herds in North America and has now been identified in wild reindeer and moose in Norway, Finland and Sweden. There is limited knowledge about the variety and characteristics of isolates or strains of CWD that exist in the landscape and their implications on wild and captive cervid herds. In this study, we evaluated brain samples from two captive elk herds that had differing prevalence, history and timelines of CWD incidence. Site 1 had a 16-year history of CWD with a consistently low prevalence between 5% and 10%. Twelve of fourteen naïve animals placed on the site remained CWD negative after 5 years of residence. Site 2 herd had a nearly 40-year known history of CWD with long-term environmental accrual of prion leading to nearly 100% of naïve animals developing clinical CWD within two to 12 years. Obex samples of several elk from each site were compared for CWD prion strain deposition, genotype in prion protein gene codon 132, and conformational stability of CWD prions. CWD prions in the obex from site 2 had a lower conformational stability than those from site 1, which was independent of prnp genotype at codon 132. These findings suggest the existence of different CWD isolates between the two sites and suggest potential differential disease attack rates for different CWD strains.

Keywords: CWD; Cervus elaphus; cervus canadensis; chronic wasting disease; conformational stability; disease prevalence; elk; isolates; prion; strains

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