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Front Surg. 2021 Dec 02;8:754741. doi: 10.3389/fsurg.2021.754741. eCollection 2021.

Bladder Cancer Sample Handling and Reporting: Pathologist's Point of View.

Frontiers in surgery

Roberta Mazzucchelli, Daniela Marzioni, Giovanni Tossetta, Laura Pepi, Rodolfo Montironi

Affiliations

  1. Section of Pathological Anatomy, Department of Biomedical Sciences and Public Health, Università Politecnica delle Marche, Ancona, Italy.
  2. Departement of Experimental and Clinical Medicine, Università Politecnica delle Marche, Ancona, Italy.

PMID: 34926567 PMCID: PMC8674620 DOI: 10.3389/fsurg.2021.754741

Abstract

The aim of this narrative review is to provide adequate information on handling and reporting of the bladder cancer samples to improve the closely collaboration between pathologists and urologists. The main (but not exclusive) research tool used was PubMed and 87 references were selected and quoted in the text. We have considered handling of biopsies, transurethral resection (TUR), and cystectomy specimens to summarize the different methods of sampling and the related issues. Moreover, we considered and discussed the main prognostic factors, such as histological tumor type, grade, and stage of bladder cancer, that should be described in the pathological report. In addition, critical issues encountered in the interpretation of histological samples were discussed.

Copyright © 2021 Mazzucchelli, Marzioni, Tossetta, Pepi and Montironi.

Keywords: bladder; carcinoma; cystectomy; handling; reporting; staging

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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