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Front Cell Dev Biol. 2021 Nov 30;9:718560. doi: 10.3389/fcell.2021.718560. eCollection 2021.

Arhgap21 Deficiency Results in Increase of Osteoblastic Lineage Cells in the Murine Bone Marrow Microenvironment.

Frontiers in cell and developmental biology

Mariana Ferreira Pissarra, Cristiane Okuda Torello, Rafael Gonçalves Barbosa Gomes, Rodrigo Naoto Shiraishi, Irene Santos, Karla Priscila Vieira Ferro, Matheus Rodrigues Lopes, Patricia Maria Bergamo Favaro, Sara Teresinha Olalla Saad, Mariana Lazarini

Affiliations

  1. Hematology and Hemotherapy Center, University of Campinas, São Paulo, Brazil.
  2. Institute of Environmental, Chemical and Pharmaceutical Sciences-Federal University of São Paulo, São Paulo, Brazil.

PMID: 34917608 PMCID: PMC8670086 DOI: 10.3389/fcell.2021.718560

Abstract

ARHGAP21 is a member of the RhoGAP family of proteins involved in cell growth, differentiation, and adhesion. We have previously shown that the heterozygous Arhgap21 knockout mouse model (Arhgap21

Copyright © 2021 Pissarra, Torello, Gomes, Shiraishi, Santos, Vieira Ferro, Lopes, Bergamo Favaro, Olalla Saad and Lazarini.

Keywords: Cdc42 (cell division cycle 42 GTP-binding protein); Rho GTPase; RhoA; RhoGAP; acute myeloid leukemia; myelodysplastic syndromes; osteocalcin

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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