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Mathelin C, Barranger E, Boisserie-Lacroix M, et al. Indications des mastectomies de réduction de risque en dehors du risque avéré de prédisposition héréditaire: recommandations du Collège National des Gynécologues et Obstétriciens Français (CNGOF). [Non-genetic indications for risk reducing mastectomies: Guidelines of the National College of French Gynecologists and Obstetricians (CNGOF)]. Gynecol Obstet Fertil Senol. 2021;doi: 10.1016/j.gofs.2021.12.005.
Mathelin, C., Barranger, E., Boisserie-Lacroix, M., Boutet, G., Brousse, S., Chabbert-Buffet, N., Coutant, C., Daraï, E., Delpech, Y., Duraes, M., Espié, M., Fornecker, L., Golfier, F., Grosclaude, P., Hamy, A. S., Kermarrec, E., Lavoué, V., Lodi, M., Luporsi, �. �., Maugard, C. M., Molière, S., Seror, J. Y., Taris, N., Uzan, C., Vaysse, C., & Fritel, X. (2021). Indications des mastectomies de réduction de risque en dehors du risque avéré de prédisposition héréditaire: recommandations du Collège National des Gynécologues et Obstétriciens Français (CNGOF). [Non-genetic indications for risk reducing mastectomies: Guidelines of the National College of French Gynecologists and Obstetricians (CNGOF)]. Gynecologie, obstetrique, fertilite & senologie, . https://doi.org/10.1016/j.gofs.2021.12.005
Mathelin, Carole, et al. "Indications des mastectomies de réduction de risque en dehors du risque avéré de prédisposition héréditaire: recommandations du Collège National des Gynécologues et Obstétriciens Français (CNGOF)." [Non-genetic indications for risk reducing mastectomies: Guidelines of the National College of French Gynecologists and Obstetricians (CNGOF)]. Gynecologie, obstetrique, fertilite & senologie vol. (2021). doi: https://doi.org/10.1016/j.gofs.2021.12.005
Mathelin C, Barranger E, Boisserie-Lacroix M, Boutet G, Brousse S, Chabbert-Buffet N, Coutant C, Daraï E, Delpech Y, Duraes M, Espié M, Fornecker L, Golfier F, Grosclaude P, Hamy AS, Kermarrec E, Lavoué V, Lodi M, Luporsi É, Maugard CM, Molière S, Seror JY, Taris N, Uzan C, Vaysse C, Fritel X. Indications des mastectomies de réduction de risque en dehors du risque avéré de prédisposition héréditaire: recommandations du Collège National des Gynécologues et Obstétriciens Français (CNGOF). [Non-genetic indications for risk reducing mastectomies: Guidelines of the National College of French Gynecologists and Obstetricians (CNGOF)]. Gynecol Obstet Fertil Senol. 2021 Dec 14; doi: 10.1016/j.gofs.2021.12.005. Epub 2021 Dec 14. French. PMID: 34920167.
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Gynecol Obstet Fertil Senol. 2021 Dec 14; doi: 10.1016/j.gofs.2021.12.005. Epub 2021 Dec 14.

[Non-genetic indications for risk reducing mastectomies: Guidelines of the National College of French Gynecologists and Obstetricians (CNGOF)].

Gynecologie, obstetrique, fertilite & senologie

[Article in French]
Carole Mathelin, Emmanuel Barranger, Martine Boisserie-Lacroix, Gérard Boutet, Susie Brousse, Nathalie Chabbert-Buffet, Charles Coutant, Emile Daraï, Yann Delpech, Martha Duraes, Marc Espié, Luc Fornecker, François Golfier, Pascale Grosclaude, Anne Sophie Hamy, Edith Kermarrec, Vincent Lavoué, Massimo Lodi, Élisabeth Luporsi, Christine M Maugard, Sébastien Molière, Jean-Yves Seror, Nicolas Taris, Catherine Uzan, Charlotte Vaysse, Xavier Fritel

Affiliations

  1. CHRU avenue Molière 67200 Strasbourg et ICANS 17 rue Albert Calmette, 67033 Strasbourg cedex, France. Electronic address: [email protected].
  2. Centre Antoine Lacassagne 36 avenue de Valombrose, 06189 Nice, France. Electronic address: [email protected].
  3. Institut Bergonié, 229 cours de l'Argonne, 33000 Bordeaux, France. Electronic address: [email protected].
  4. AGREGA, service de chirurgie gynécologique et médecine de la reproduction, centre Aliénor d'Aquitaine, centre hospitalier universitaire de Bordeaux, groupe hospitalier Pellegrin, place Amélie-Raba-Léon, 33000 Bordeaux, France. Electronic address: [email protected].
  5. CHU de Rennes, 2 Rue Henri le Guilloux, 35033 Rennes cedex 9, France. Electronic address: [email protected].
  6. Hôpital Tenon Service de Gynécologie-obstétrique 4 rue de la Chine, 75020 Paris, France. Electronic address: [email protected].
  7. Département d'oncologie chirurgicale Centre Georges François Leclerc 1 rue du Pr Marion, 21079 Dijon cedex, France. Electronic address: [email protected].
  8. Hôpital Tenon Service de Gynécologie-obstétrique 4 rue de la Chine, 75020 Paris, France. Electronic address: [email protected].
  9. Centre Antoine Lacassagne 33 Avenue de Valombrose, 06189 Nice, France. Electronic address: [email protected].
  10. CHU de Montpellier, 191 avenue du Doyen Giraud, 34295 Montpellier Cedex, France. Electronic address: [email protected].
  11. Hôpital St Louis 1 avenue Claude Vellefaux, 75010 Paris, France. Electronic address: [email protected].
  12. Département d'onco-hématologie, ICANS 17 rue Albert Calmette, 67033 Strasbourg cedex, France. Electronic address: [email protected].
  13. Centre Hospitalier Lyon Sud Batiment 3B 165 chemin du Grand Revoyet, 69495 Pierre Benite, France. Electronic address: [email protected].
  14. CERPOP, Inserm. Université Toulouse III, 31059 Toulouse, France. Electronic address: [email protected].
  15. Institut Curie 26 rue d'Ulm, 75248 Paris, France. Electronic address: [email protected].
  16. Hôpital Tenon Service de radiologie 4 rue de la Chine, 75020 Paris, France. Electronic address: [email protected].
  17. CHU Service de Gynécologie 16 boulevard de Bulgarie, 35200 Rennes, France. Electronic address: [email protected].
  18. CHU avenue Molière, 67200 Strasbourg, France. Electronic address: [email protected].
  19. Oncologie médicale et Oncogénétique, CHR Metz-Thionville, Hôpital de Mercy, 1 allée du château, 57085 Metz, France. Electronic address: [email protected].
  20. Service de Génétique oncologique clinique et Unité de Génétique Oncologique Moléculaire, Hôpitaux Universitaires de Strasbourg, 1 Avenue Molière, 67200 Strasbourg, France. Electronic address: [email protected].
  21. Imagerie du Sein, CHRU Avenue Molière, 67200 Strasbourg, France. Electronic address: [email protected].
  22. 9 ter boulevard Montparnasse, 75006 Paris, France. Electronic address: [email protected].
  23. Oncogénétique, ICANS 17 rue Albert Calmette, 67033 Strasbourg, France. Electronic address: [email protected].
  24. Hôpital Pitié Salpetrière 47 bld de l'Hôpital, 75013 Paris, France. Electronic address: [email protected].
  25. Service de chirurgie oncologique, CHU Toulouse, Institut Universitaire du Cancer de Toulouse-Oncopole, 1 avenue Irène Joliot Curie, 31059 Toulouse, France. Electronic address: [email protected].
  26. Centre hospitalo-universitaire de Poitiers, 2 Rue de la Milétrie, 86021 Poitiers, France. Electronic address: [email protected].

PMID: 34920167 DOI: 10.1016/j.gofs.2021.12.005

Abstract

OBJECTIVE: To determine the value of performing a risk-reducting mastectomy (RRM) in the absence of a deleterious variant of a breast cancer susceptibility gene, in 4 clinical situations at risk of breast cancer.

DESIGN: The CNGOF Commission of Senology, composed of 26 experts, developed these recommendations. A policy of declaration and monitoring of links of interest was applied throughout the process of making the recommendations. Similarly, the development of these recommendations did not benefit from any funding from a company marketing a health product. The Commission of Senology adhered to the AGREE II (Advancing guideline development, reporting and evaluation in healthcare) criteria and followed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) method to assess the quality of the evidence on which the recommendations were based. The potential drawbacks of making recommendations in the presence of poor quality or insufficient evidence were highlighted.

METHODS: The Commission of Senology considered 8 questions on 4 topics, focusing on histological, familial (no identified genetic abnormality), radiological (of unrecognized cancer), and radiation (history of Hodgkin's disease) risk. For each situation, it was determined whether performing RRM compared with surveillance would decrease the risk of developing breast cancer and/or increase survival.

RESULTS: The Commission of Senology synthesis and application of the GRADE method resulted in 11 recommendations, 6 with a high level of evidence (GRADE 1+/-) and 5 with a low level of evidence (GRADE 2+/-).

CONCLUSION: There was significant agreement among the Commission of Senology members on recommendations to improve practice for performing or not performing RRM in the clinical setting.

Copyright © 2021. Published by Elsevier Masson SAS.

Keywords: breast cancer; cancer du sein; chirurgie; mastectomie de réduction de risque; mastectomie préventive; prevention; prophylactic mastectomy; prévention; risk reducing mastectomy; surgery

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