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Ji JS, Liu L, Shu C, et al. Sex Difference and Interaction of SIRT1 and FOXO3 Candidate Longevity Genes on Life Expectancy: A 10-year Prospective Longitudinal Cohort Study. J Gerontol A Biol Sci Med Sci. 2021;doi: 10.1093/gerona/glab378.
Ji, J. S., Liu, L., Shu, C., Yan, L. L., & Zeng, Y. (2021). Sex Difference and Interaction of SIRT1 and FOXO3 Candidate Longevity Genes on Life Expectancy: A 10-year Prospective Longitudinal Cohort Study. The journals of gerontology. Series A, Biological sciences and medical sciences, . https://doi.org/10.1093/gerona/glab378
Ji, John S, et al. "Sex Difference and Interaction of SIRT1 and FOXO3 Candidate Longevity Genes on Life Expectancy: A 10-year Prospective Longitudinal Cohort Study." The journals of gerontology. Series A, Biological sciences and medical sciences vol. (2021). doi: https://doi.org/10.1093/gerona/glab378
Ji JS, Liu L, Shu C, Yan LL, Zeng Y. Sex Difference and Interaction of SIRT1 and FOXO3 Candidate Longevity Genes on Life Expectancy: A 10-year Prospective Longitudinal Cohort Study. J Gerontol A Biol Sci Med Sci. 2021 Dec 20; doi: 10.1093/gerona/glab378. Epub 2021 Dec 20. PMID: 34928346.
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J Gerontol A Biol Sci Med Sci. 2021 Dec 20; doi: 10.1093/gerona/glab378. Epub 2021 Dec 20.

Sex Difference and Interaction of SIRT1 and FOXO3 Candidate Longevity Genes on Life Expectancy: A 10-year Prospective Longitudinal Cohort Study.

The journals of gerontology. Series A, Biological sciences and medical sciences

John S Ji, Linxin Liu, Chang Shu, Lijing L Yan, Yi Zeng

Affiliations

  1. Vanke School of Public Health, Tsinghua University, Beijing, China.
  2. Global Health Research Center, Duke Kunshan University, Kunshan, China.
  3. Department of Pediatrics & Department of System Biology, Columbia University, New York, USA.
  4. Center for Healthy Aging and Development Studies, National School of Development, Peking University, Beijing, China.
  5. Center for the Study of Aging and Human Development, Duke Medical School, Durham, NC, USA.

PMID: 34928346 DOI: 10.1093/gerona/glab378

Abstract

SIRT1 and FOXO3 are both associated with longevity. Molecular biology research in many organisms (yeast, nematode worm Caenorhabditis elegans, and mice mammalian models) shows SIRT1 acts on the FOXO family of forkhead transcription factors to respond to oxidative stress better, shifting processes away from cell death towards stress resistance. Human population studies need epidemiologic evidence. We used an open cohort of 3,166 community-dwelling participants in China with follow-up from 2008 to 2018. The mean age at baseline was 84.6 years. In 16,375 person-years of follow-up, there were 1,968 mortality events. SIRT1 and FOXO3 exhibited mendelian randomization as there was no correlation with each other and with baseline study population characteristics. Some SIRT1 and FOXO3 SNPs showed protective effects for mortality risk. The FOXO3 protective effect was stronger in females, and the SIRT1 protective effect was stronger in male study participants. We did not see evidence of a synergistic effect of being carriers of both SIRT1 and FOXO3.

© The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: [email protected].

Keywords: Effect modification; FOXO3; Gene-gene interaction; Longevity; SIRT1; Sex difference

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