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Mohamdeen YMG, Tabriz AG, Tighsazzadeh M, et al. Development of 3D printed drug-eluting contact lenses. J Pharm Pharmacol. 2021;doi: 10.1093/jpp/rgab173.
Mohamdeen, Y. M. G., Tabriz, A. G., Tighsazzadeh, M., Nandi, U., Khalaj, R., Andreadis, I., Boateng, J. S., & Douroumis, D. (2021). Development of 3D printed drug-eluting contact lenses. The Journal of pharmacy and pharmacology, . https://doi.org/10.1093/jpp/rgab173
Mohamdeen, Youssra Moustafa Gadelkareem, et al. "Development of 3D printed drug-eluting contact lenses." The Journal of pharmacy and pharmacology vol. (2021). doi: https://doi.org/10.1093/jpp/rgab173
Mohamdeen YMG, Tabriz AG, Tighsazzadeh M, Nandi U, Khalaj R, Andreadis I, Boateng JS, Douroumis D. Development of 3D printed drug-eluting contact lenses. J Pharm Pharmacol. 2021 Dec 20; doi: 10.1093/jpp/rgab173. Epub 2021 Dec 20. PMID: 34928372.
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J Pharm Pharmacol. 2021 Dec 20; doi: 10.1093/jpp/rgab173. Epub 2021 Dec 20.

Development of 3D printed drug-eluting contact lenses.

The Journal of pharmacy and pharmacology

Youssra Moustafa Gadelkareem Mohamdeen, Atabak Ghanizadeh Tabriz, Mohammad Tighsazzadeh, Uttom Nandi, Roxanne Khalaj, Ioannis Andreadis, Joshua S Boateng, Dennis Douroumis

Affiliations

  1. Faculty of Engineering and Science, School of Science, University of Greenwich, Chatham, Kent, UK.
  2. Faculty of Biotechnology, October University for Modern Sciences and Arts (MSA), Cairo, Egypt.
  3. CIPER: Centre for Innovation and Process Engineering Research, Kent, UK.
  4. Laboratory of Pharmaceutical Technology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

PMID: 34928372 DOI: 10.1093/jpp/rgab173

Abstract

OBJECTIVES: The aim of the work was to introduce 3D printing technology for the design and fabrication of drug-eluting contact lenses (DECL) for the treatment of glaucoma. The development of 3D printed lenses can effectively overcome drawbacks of existing approaches by using biocompatible medical grade polymers that provide sustained drug release of timolol maleate for extended periods.

METHODS: Hot melt extrusion was coupled with fusion deposition modelling (FDM) to produce printable filaments of ethylene-vinyl acetate copolymer-polylactic acid blends at various ratios loaded with timolol maleate. Physicochemical and mechanical characterisation of the printed filaments was used to optimise the printing of the contact lenses.

KEY FINDINGS: 3D printed lenses with an aperture (opening) and specified dimensions could be printed using FDM technology. The lenses presented a smooth surface with good printing resolution while providing sustained release of timolol maleate over 3 days. The findings of this study can be used for the development of personalised DECL in the future.

© The Author(s) 2021. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved. For permissions, please e-mail: [email protected].

Keywords: 3D printing; contact lenses; fusion deposition modelling; glaucoma; hot melt extrusion; medical biodegradable

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