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Boulan B, Ravanello C, Peyrel A, et al. CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway. Elife. 2021;10doi: 10.7554/eLife.70361.
Boulan, B., Ravanello, C., Peyrel, A., Bosc, C., Delphin, C., Appaix, F., Denarier, E., Kraut, A., Jaquier-Sarlin, M., Fournier, A., Andrieux, A., Gory-Fauré, S., & Deloulme, J. C. (2021). CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway. eLife, 10. https://doi.org/10.7554/eLife.70361
Boulan, Benoît, et al. "CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway." eLife vol. 10 (2021). doi: https://doi.org/10.7554/eLife.70361
Boulan B, Ravanello C, Peyrel A, Bosc C, Delphin C, Appaix F, Denarier E, Kraut A, Jaquier-Sarlin M, Fournier A, Andrieux A, Gory-Fauré S, Deloulme JC. CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway. Elife. 2021 Dec 03;10. doi: 10.7554/eLife.70361. PMID: 34860155.
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Elife. 2021 Dec 03;10. doi: 10.7554/eLife.70361.

CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway.

eLife

Benoît Boulan, Charlotte Ravanello, Amandine Peyrel, Christophe Bosc, Christian Delphin, Florence Appaix, Eric Denarier, Alexandra Kraut, Muriel Jaquier-Sarlin, Alyson Fournier, Annie Andrieux, Sylvie Gory-Fauré, Jean-Christophe Deloulme

Affiliations

  1. Univ. Grenoble Alpes, Inserm, U1216, CEA, Grenoble Institut Neurosciences, Grenoble, France.
  2. Univ. Grenoble Alpes, Inserm, CEA, UMR BioSanté U1292, CNRS, CEA, Grenoble, France.
  3. Department of Neurology and Neurosurgery, Montréal Neurological Institute, McGill University, Montréal, Canada.

PMID: 34860155 DOI: 10.7554/eLife.70361

Abstract

Neurodevelopmental axonal pathfinding plays a central role in correct brain wiring and subsequent cognitive abilities. Within the growth cone, various intracellular effectors transduce axonal guidance signals by remodeling the cytoskeleton. Semaphorin-3E (Sema3E) is a guidance cue implicated in development of the fornix, a neuronal tract connecting the hippocampus to the hypothalamus. Microtubule-associated protein 6 (MAP6) has been shown to be involved in the Sema3E growth-promoting signaling pathway. In this study, we identified the collapsin response mediator protein 4 (CRMP4) as a MAP6 partner and a crucial effector in Sema3E growth-promoting activity. CRMP4-KO mice displayed abnormal fornix development reminiscent of that observed in Sema3E-KO mice. CRMP4 was shown to interact with the Sema3E tripartite receptor complex within detergent-

© 2021, Boulan et al.

Keywords: CRMP4; Semaphorin-3E; axonal guidance; collapsin-response-mediator-proteins; detergent-resistant membrane domains; detergent-resistant-membrane-domains; developmental biology; fornix; lipid rafts; neuroscience

Conflict of interest statement

BB, CR, AP, CB, CD, FA, ED, AK, MJ, AF, AA, SG, JD No competing interests declared

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Grant support