J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20211971. Epub 2021 Oct 29.

Blood-thirsty: S1PR5 and TRM.

The Journal of experimental medicine

Victoria M Hallisey, Susan R Schwab

PMID: 34714328 PMCID: PMC8574975 DOI: 10.1084/jem.20211971

Abstract

In this elegant study, Evrard et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210116) find that sphingosine 1-phosphate receptor 5 (S1PR5) powerfully impairs tissue-resident memory T cell (TRM) formation, and that tissue-derived TGF-β limits S1pr5 expression by infiltrating T cells.

© 2021 Hallisey and Schwab.

References

1. Annu Rev Immunol. 2020 Apr 26;38:759-784 - PubMed
2. Nat Immunol. 2020 Sep;21(9):1070-1081 - PubMed
3. Science. 2011 Sep 30;333(6051):1898-903 - PubMed
4. Nat Immunol. 2013 Dec;14(12):1285-93 - PubMed
5. Nature. 2006 Mar 23;440(7083):540-4 - PubMed
6. J Exp Med. 2018 Apr 2;215(4):1153-1168 - PubMed
7. J Exp Med. 2015 Nov 16;212(12):2041-56 - PubMed
8. J Immunol. 2015 Mar 1;194(5):2059-63 - PubMed
9. J Exp Med. 2009 Oct 26;206(11):2469-81 - PubMed
10. J Biol Chem. 2001 Feb 23;276(8):5692-9 - PubMed
11. Science. 2002 Apr 12;296(5566):346-9 - PubMed
12. Nat Immunol. 2007 Dec;8(12):1337-44 - PubMed
13. Nat Immunol. 2020 Apr;21(4):412-421 - PubMed
14. J Exp Med. 2022 Jan 3;219(1): - PubMed

Substances

• Sphingosine-1-Phosphate Receptors

MeSH terms

• Memory T Cells*
• Sphingosine-1-Phosphate Receptors

Publication Types

• Journal Article
• Comment