Display options
Cite
Piacenza F, Giacconi R, Costarelli L, et al. Age, Sex, and BMI Influence on Copper, Zinc, and Their Major Serum Carrier Proteins in a Large European Population Including Nonagenarian Offspring From MARK-AGE Study. J Gerontol A Biol Sci Med Sci. 2021;76(12):2097-2106doi: 10.1093/gerona/glab134.
Piacenza, F., Giacconi, R., Costarelli, L., Basso, A., Bürkle, A., Moreno-Villanueva, M., Dollé, M. E. T., Jansen, E., Grune, T., Weber, D., Stuetz, W., Gonos, E. S., Schön, C., Bernhardt, J., Grubeck-Loebenstein, B., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Franceschi, C., Capri, M., Hervonen, A., Hurme, M., Slagboom, E., Breusing, N., Mocchegiani, E., & Malavolta, M. (2021). Age, Sex, and BMI Influence on Copper, Zinc, and Their Major Serum Carrier Proteins in a Large European Population Including Nonagenarian Offspring From MARK-AGE Study. The journals of gerontology. Series A, Biological sciences and medical sciences, 76(12), 2097-2106. https://doi.org/10.1093/gerona/glab134
Piacenza, Francesco, et al. "Age, Sex, and BMI Influence on Copper, Zinc, and Their Major Serum Carrier Proteins in a Large European Population Including Nonagenarian Offspring From MARK-AGE Study." The journals of gerontology. Series A, Biological sciences and medical sciences vol. 76,12 (2021): 2097-2106. doi: https://doi.org/10.1093/gerona/glab134
Piacenza F, Giacconi R, Costarelli L, Basso A, Bürkle A, Moreno-Villanueva M, Dollé MET, Jansen E, Grune T, Weber D, Stuetz W, Gonos ES, Schön C, Bernhardt J, Grubeck-Loebenstein B, Sikora E, Toussaint O, Debacq-Chainiaux F, Franceschi C, Capri M, Hervonen A, Hurme M, Slagboom E, Breusing N, Mocchegiani E, Malavolta M. Age, Sex, and BMI Influence on Copper, Zinc, and Their Major Serum Carrier Proteins in a Large European Population Including Nonagenarian Offspring From MARK-AGE Study. J Gerontol A Biol Sci Med Sci. 2021 Nov 15;76(12):2097-2106. doi: 10.1093/gerona/glab134. PMID: 33983441.
Copy Download .nbib Format: NLM
Share it on

J Gerontol A Biol Sci Med Sci. 2021 Nov 15;76(12):2097-2106. doi: 10.1093/gerona/glab134.

Age, Sex, and BMI Influence on Copper, Zinc, and Their Major Serum Carrier Proteins in a Large European Population Including Nonagenarian Offspring From MARK-AGE Study.

The journals of gerontology. Series A, Biological sciences and medical sciences

Francesco Piacenza, Robertina Giacconi, Laura Costarelli, Andrea Basso, Alexander Bürkle, María Moreno-Villanueva, Martijn E T Dollé, Eugène Jansen, Tilman Grune, Daniela Weber, Wolfgang Stuetz, Efstathios S Gonos, Christiane Schön, Jürgen Bernhardt, Beatrix Grubeck-Loebenstein, Ewa Sikora, Olivier Toussaint, Florence Debacq-Chainiaux, Claudio Franceschi, Miriam Capri, Antti Hervonen, Mikko Hurme, Eline Slagboom, Nicolle Breusing, Eugenio Mocchegiani, Marco Malavolta

Affiliations

  1. Translational Research Center of Nutrition and Ageing, IRCCS INRCA, Ancona, Italy.
  2. Department of Biology, University of Konstanz, Germany.
  3. Human Performance Research Centre, Department of Sport Science, University of Konstanz, Germany.
  4. Centre for Health Protection, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  5. Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
  6. NutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, Nuthetal, Germany.
  7. Institute of Nutritional Sciences, University of Hohenheim, Stuttgart, Germany.
  8. National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece.
  9. BioTeSys GmbH, Esslingen, Germany.
  10. Research Institute for Biomedical Aging Research, University of Innsbruck, Austria.
  11. Laboratory of the Molecular Bases of Ageing, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
  12. URBC-NARILIS, University of Namur, Belgium.
  13. Department of Applied Mathematics, Lobachevsky University, Nizhny Novgorod, Russia.
  14. Department of Experimental, Diagnostic and Specialty Medicine (DIMES) and CIG-Interdepartmental Center "L. Galvani," Alma Mater Studiorum, University of Bologna, Italy.
  15. Interdepartmental Center "Alma Mater Research Institute on Global Challenges and Climate Change (Alma Climate)," Alma Mater Studiorum, University of Bologna, Italy.
  16. Medical School, University of Tampere, Finland.
  17. Department of Molecular Epidemiology, Leiden University Medical Centre, The Netherlands.
  18. Department of Applied Nutritional Science/Dietetics, Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.

PMID: 33983441 DOI: 10.1093/gerona/glab134

Abstract

The analysis of copper (Cu) and zinc (Zn) along with their major serum carriers, albumin (Alb) and ceruloplasmin (Cp), could provide information on the capacity of humans to maintain homeostasis of metals (metallostasis). However, their relationship with aging, sex, body mass index, as well as with nutritional and inflammatory markers was never investigated in a large-scale study. Here, we report results from the European large-scale cross-sectional study MARK-AGE in which Cu, Zn, Alb, Cp, as well as nutritional and inflammatory parameters were determined in 2424 age-stratified participants (35-75 years), including the general population (RASIG), nonagenarian offspring (GO), a well-studied genetic model of longevity, and spouses of GO (SGO). In RASIG, Cu to Zn ratio and Cp to Alb ratio were higher in women than in men. Both ratios increased with aging because Cu and Cp increased and Alb and Zn decreased. Cu, Zn, Alb, and Cp were found associated with several inflammatory as well as nutritional biomarkers. GO showed higher Zn levels and higher Zn to Alb ratio compared to RASIG, but we did not observe significant differences with SGO, likely as a consequence of the low sample size of SGO and the shared environment. Our results show that aging, sex, body mass index, and GO status are characterized by different levels of Cu, Zn, and their serum carrier proteins. These data and their relationship with inflammatory biomarkers support the concept that loss of metallostasis is a characteristic of inflammaging.

© The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: [email protected].

Keywords: Albumin; Ceruloplasmin; Chronic inflammatory status; Homeostasis; Metallostasis

Publication Types