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Hanssen E, van Buuren M, Van Atteveldt N, et al. Neural, behavioural and real-life correlates of social context sensitivity and social reward learning during interpersonal interactions in the schizophrenia spectrum. Aust N Z J Psychiatry. 2021;56(1):59-70doi: 10.1177/00048674211010327.
Hanssen, E., van Buuren, M., Van Atteveldt, N., Lemmers-Jansen, I. L., & Fett, A. J. (2022). Neural, behavioural and real-life correlates of social context sensitivity and social reward learning during interpersonal interactions in the schizophrenia spectrum. The Australian and New Zealand journal of psychiatry, 56(1), 59-70. https://doi.org/10.1177/00048674211010327
Hanssen, Esther, et al. "Neural, behavioural and real-life correlates of social context sensitivity and social reward learning during interpersonal interactions in the schizophrenia spectrum." The Australian and New Zealand journal of psychiatry vol. 56,1 (2022): 59-70. doi: https://doi.org/10.1177/00048674211010327
Hanssen E, van Buuren M, Van Atteveldt N, Lemmers-Jansen IL, Fett AJ. Neural, behavioural and real-life correlates of social context sensitivity and social reward learning during interpersonal interactions in the schizophrenia spectrum. Aust N Z J Psychiatry. 2022 Jan;56(1):59-70. doi: 10.1177/00048674211010327. Epub 2021 May 18. PMID: 34006142.
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Aust N Z J Psychiatry. 2022 Jan;56(1):59-70. doi: 10.1177/00048674211010327. Epub 2021 May 18.

Neural, behavioural and real-life correlates of social context sensitivity and social reward learning during interpersonal interactions in the schizophrenia spectrum.

The Australian and New Zealand journal of psychiatry

Esther Hanssen, Mariët van Buuren, Nienke Van Atteveldt, Imke Lj Lemmers-Jansen, Anne-Kathrin J Fett

Affiliations

  1. Department of Clinical, Neuro and Developmental Psychology, Faculty of Behavioural and Movement Sciences, and Institute for Brain and Behaviour (IBBA) Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  2. CSI Lab, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychosis Studies, King's College London, London, UK.
  3. Hersencentrum Mental Health Institute, Amsterdam, The Netherlands.
  4. Department of Psychology, City, University of London, London, UK.

PMID: 34006142 DOI: 10.1177/00048674211010327

Abstract

OBJECTIVE: Recent findings suggest that diminished processing of positive contextual information about others during interactions may contribute to social impairment in the schizophrenia spectrum. This could be due to general social context processing deficits or specific biases against positive information. We studied the impact of positive and negative social contextual information during social interactions using functional neuroimaging and probed whether these neural mechanisms were associated with real-life social functioning in schizophrenia spectrum disorders.

METHODS: Patients with a schizophrenia spectrum disorder (

RESULTS: Social contextual information had no effect on patients' first investments, whereas controls made the lowest investment after negative and the highest investments after positive contextual information was provided. Over trials, patients decreased investments, suggesting reduced social reward learning, whereas controls increased investments in response to behavioural feedback in the negative context. Patients engaged the dorsolateral prefrontal cortex less than controls during context presentation and showed reduced activity within the caudate during repayments. In patients, lower investments were associated with more time spent alone and social exclusion and lower caudate activation was marginally significantly associated with higher perceived social exclusion.

CONCLUSION: The failure to adapt trust to positive and negative social contexts suggests that patients have a general insensitivity to prior social information, indicating top-down processing impairments. In addition, patients show reduced sensitivity to social reward, i.e. bottom-up processing deficits. Moreover, lower trust and lower neural activation were related to lower real-life social functioning. Together, these findings indicate that improving trust and social interactions in schizophrenia spectrum needs a multi-faceted approach that targets both mechanisms.

Keywords: Functional magnetic resonance imaging; experience sampling method; schizophrenia; social context processing; trust

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