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Hong X, Campanario S, Ramírez-Pardo I, et al. Stem cell aging in the skeletal muscle: The importance of communication. Ageing Res Rev. 2021;73:101528doi: 10.1016/j.arr.2021.101528.
Hong, X., Campanario, S., Ramírez-Pardo, I., Grima-Terrén, M., Isern, J., & Muñoz-Cánoves, P. (2022). Stem cell aging in the skeletal muscle: The importance of communication. Ageing research reviews, 73101528. https://doi.org/10.1016/j.arr.2021.101528
Hong, Xiaotong, et al. "Stem cell aging in the skeletal muscle: The importance of communication." Ageing research reviews vol. 73 (2022): 101528. doi: https://doi.org/10.1016/j.arr.2021.101528
Hong X, Campanario S, Ramírez-Pardo I, Grima-Terrén M, Isern J, Muñoz-Cánoves P. Stem cell aging in the skeletal muscle: The importance of communication. Ageing Res Rev. 2022 Jan;73:101528. doi: 10.1016/j.arr.2021.101528. Epub 2021 Nov 21. PMID: 34818593.
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Ageing Res Rev. 2022 Jan;73:101528. doi: 10.1016/j.arr.2021.101528. Epub 2021 Nov 21.

Stem cell aging in the skeletal muscle: The importance of communication.

Ageing research reviews

Xiaotong Hong, Silvia Campanario, Ignacio Ramírez-Pardo, Mercedes Grima-Terrén, Joan Isern, Pura Muñoz-Cánoves

Affiliations

  1. Centro Nacional de Investigaciones Cardiovasculares (CNIC), E-28029 Madrid, Spain; Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED), E-08003 Barcelona, Spain.
  2. Centro Nacional de Investigaciones Cardiovasculares (CNIC), E-28029 Madrid, Spain; Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED), E-08003 Barcelona, Spain; ICREA, E-08010 Barcelona, Spain. Electronic address: [email protected].

PMID: 34818593 DOI: 10.1016/j.arr.2021.101528

Abstract

Adult stem cells sustain tissue homeostasis and regeneration; their functional decline is often linked to aging, which is characterized by the progressive loss of physiological functions across multiple tissues and organs. The resident stem cells in skeletal muscle, termed satellite cells, are normally quiescent but activate upon injury to reconstitute the damaged tissue. In this review, we discuss the current understanding of the molecular processes that contribute to the functional failure of satellite cells during aging. This failure is due not only to intrinsic changes but also to extrinsic factors, most of which are still undefined but originate from the muscle tissue microenvironment of the satellite cells (the niche), or from the systemic environment. We also highlight the emerging applications of the powerful single-cell sequencing technologies in the study of skeletal muscle aging, particularly in the heterogeneity of the satellite cell population and the molecular interaction of satellite cells and other cell types in the niche. An improved understanding of how satellite cells communicate with their environment, and how this communication is perturbed with aging, will be helpful for defining countermeasures against loss of muscle regenerative capacity in sarcopenia.

Copyright © 2021. Published by Elsevier B.V.

Keywords: Aging; Niche; Rejuvenation; Satellite cell; Single-cell omics; Skeletal muscle regeneration; Stem cell

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