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de Oliveira Lima IG, Bispo JRS, da Silva MB, et al. Technological Prospecting: Mapping Patents on L-asparaginases from Extremophilic Microorganisms. Recent Pat Biotechnol. 2021;15(4):250-265doi: 10.2174/1872208315666210805162459.
de Oliveira Lima, I. G., Bispo, J. R. S., da Silva, M. B., de Oliveira Feitosa, A., Dos Santos, A. C. M., Moreira, M. S. A., Passarini, M. R. Z., Saraiva Câmara, P. E. A., Rosa, L. H., Oliveira, V. M., de Queiroz, A. C., & Duarte, A. W. F. (2021). Technological Prospecting: Mapping Patents on L-asparaginases from Extremophilic Microorganisms. Recent patents on biotechnology, 15(4), 250-265. https://doi.org/10.2174/1872208315666210805162459
de Oliveira Lima, Igor Gomes, et al. "Technological Prospecting: Mapping Patents on L-asparaginases from Extremophilic Microorganisms." Recent patents on biotechnology vol. 15,4 (2021): 250-265. doi: https://doi.org/10.2174/1872208315666210805162459
de Oliveira Lima IG, Bispo JRS, da Silva MB, de Oliveira Feitosa A, Dos Santos ACM, Moreira MSA, Passarini MRZ, Saraiva Câmara PEA, Rosa LH, Oliveira VM, de Queiroz AC, Duarte AWF. Technological Prospecting: Mapping Patents on L-asparaginases from Extremophilic Microorganisms. Recent Pat Biotechnol. 2021;15(4):250-265. doi: 10.2174/1872208315666210805162459. PMID: 34353277.
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Recent Pat Biotechnol. 2021;15(4):250-265. doi: 10.2174/1872208315666210805162459.

Technological Prospecting: Mapping Patents on L-asparaginases from Extremophilic Microorganisms.

Recent patents on biotechnology

Igor Gomes de Oliveira Lima, James Romero Soares Bispo, Maurício Bernardo da Silva, Alexya de Oliveira Feitosa, Ana Caroline Melo Dos Santos, Magna Suzana Alexandre Moreira, Michel Rodrigo Zambrano Passarini, Paulo Eduardo Aguiar Saraiva Câmara, Luiz Henrique Rosa, Valéria Maia Oliveira, Aline Cavalcanti de Queiroz, Alysson Wagner Fernandes Duarte

Affiliations

  1. Laboratorio de Microbiologia, Imunologia e Parasitologia, Complexo de Ciencias Medicas e Enfermagem, Campus Arapiraca, Universidade Federal de Alagoas, 57309-005, Arapiraca, AL, Brazil.
  2. Laboratorio de Farmacologia e Imunologia, Instituto de Ciencias Biologicas e da Saude, Universidade Federal de Alagoas, 57072-900, Maceio, AL, Brazil.
  3. Universidade Federal da Integracao Latino-Americana, 85870-650, Foz Do Iguacu, PR, Brazil.
  4. Departamento de Botanica, Campus Darcy Ribeiro, Universidade de Brasília, Asa Norte, s/n, 70910-900, Brasilia, DF, Brazil.
  5. Departamento de Microbiologia, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil.
  6. Divisao de Recursos Microbianos, Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas. Universidade Estadual de Campinas, UNICAMP, 13148-218, Paulinia, SP, Brazil.

PMID: 34353277 DOI: 10.2174/1872208315666210805162459

Abstract

BACKGROUND: L-asparaginase (L-ASNase, L-asparagine amidohydrolase, E.C.3.5.1.1) is an enzyme with wide therapeutic applicability. Currently, the commercialized L-ASNase comes from mesophilic organisms, presenting low specificity to the substrate and limitations regarding thermostability and active pH range. Such factors prevent the maximum performance of the enzyme in different applications. Therefore, extremophilic organisms may represent important candidates for obtaining amidohydrolases with particular characteristics desired by the biotechnological market.

OBJECTIVES: The present study aims to carry out a technological prospecting of patents related to the L-asparaginases derived from extremophilic organisms, contributing to pave the way for further rational investigation and application of such enzymes.

METHODS: This patent literature review used six patents databases: The LENS, WIPO, EPO, USPTO, Patent Inspiration, and INPI.

RESULTS: It was analyzed 2860 patents, and 14 were selected according to combinations of descriptors and study criteria. Approximately 57.14% of the patents refer to enzymes obtained from archaea, especially from the speciesPyrococcus yayanosii (35.71% of the totality).

CONCLUSION: The present prospective study has singular relevance since there are no recent patent reviews for L-asparaginases, especially produced by extremophilic microorganisms. Although such enzymes have well-defined applications, corroborated by the patents compiled in this review, the most recent studies allude to new uses, such as the treatment of infections. The characterization of the catalytic profiles allows us to infer that there are potential sources still unexplored. Hence, the search for new L-ASNases with different characteristics will continue to grow in the coming years and, possibly, ramifications of the technological routes will be witnessed.

Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Keywords: Acrylamide; L-asparaginase; L-asparagine; amidohydrolase; chemotherapeutic drug; extremophiles; patents; technology innovation.

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