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Epum EA, Haber JE. DNA replication: the recombination connection. Trends Cell Biol. 2021;32(1):45-57doi: 10.1016/j.tcb.2021.07.005.
Epum, E. A., & Haber, J. E. (2022). DNA replication: the recombination connection. Trends in cell biology, 32(1), 45-57. https://doi.org/10.1016/j.tcb.2021.07.005
Epum, Esther A, and Haber, James E. "DNA replication: the recombination connection." Trends in cell biology vol. 32,1 (2022): 45-57. doi: https://doi.org/10.1016/j.tcb.2021.07.005
Epum EA, Haber JE. DNA replication: the recombination connection. Trends Cell Biol. 2022 Jan;32(1):45-57. doi: 10.1016/j.tcb.2021.07.005. Epub 2021 Aug 09. PMID: 34384659; PMCID: PMC8688190.
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Trends Cell Biol. 2022 Jan;32(1):45-57. doi: 10.1016/j.tcb.2021.07.005. Epub 2021 Aug 09.

DNA replication: the recombination connection.

Trends in cell biology

Esther A Epum, James E Haber

Affiliations

  1. Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02254-9110, USA.
  2. Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02254-9110, USA. Electronic address: [email protected].

PMID: 34384659 PMCID: PMC8688190 DOI: 10.1016/j.tcb.2021.07.005

Abstract

Failure to complete DNA replication is one of the major sources of genome instability leading to aneuploidy, chromosome breakage, and chromosome rearrangements that are associated with human cancer. One of the surprising revelations of the past decade is that the completion of replication at so-called common fragile sites (CFS) occurs very late in the cell cycle - at mitosis - through a process termed MiDAS (mitotic DNA synthesis). MiDAS is strongly related to another cancer-promoting phenomenon: the activation of alternative lengthening of telomeres (ALT). Our understanding of the mechanisms of ALT and MiDAS in mammalian cells has drawn heavily from recent advances in the study of break-induced replication (BIR), especially in budding yeast. We provide new insights into the BIR, MiDAS, and ALT pathways and their shared similarities.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: alternative lengthening of telomeres (ALT); break-induced replication (BIR); homologous recombination; mitotic DNA synthesis (MiDAS)

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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