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Boulan B, Ravanello C, Peyrel A, et al. CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway. Elife. 2021;10doi: 10.7554/eLife.70361.
Boulan, B., Ravanello, C., Peyrel, A., Bosc, C., Delphin, C., Appaix, F., Denarier, E., Kraut, A., Jacquier-Sarlin, M., Fournier, A., Andrieux, A., Gory-Fauré, S., & Deloulme, J. C. (2021). CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway. eLife, 10. https://doi.org/10.7554/eLife.70361
Boulan, Benoît, et al. "CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway." eLife vol. 10 (2021). doi: https://doi.org/10.7554/eLife.70361
Boulan B, Ravanello C, Peyrel A, Bosc C, Delphin C, Appaix F, Denarier E, Kraut A, Jacquier-Sarlin M, Fournier A, Andrieux A, Gory-Fauré S, Deloulme JC. CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway. Elife. 2021 Dec 03;10. doi: 10.7554/eLife.70361. PMID: 34860155; PMCID: PMC8683083.
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Elife. 2021 Dec 03;10. doi: 10.7554/eLife.70361.

CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway.

eLife

Benoît Boulan, Charlotte Ravanello, Amandine Peyrel, Christophe Bosc, Christian Delphin, Florence Appaix, Eric Denarier, Alexandra Kraut, Muriel Jacquier-Sarlin, Alyson Fournier, Annie Andrieux, Sylvie Gory-Fauré, Jean-Christophe Deloulme

Affiliations

  1. Univ. Grenoble Alpes, Inserm, U1216, CEA, Grenoble Institut Neurosciences, Grenoble, France.
  2. Univ. Grenoble Alpes, Inserm, CEA, UMR BioSanté U1292, CNRS, CEA, Grenoble, France.
  3. Department of Neurology and Neurosurgery, Montréal Neurological Institute, McGill University, Montréal, Canada.

PMID: 34860155 PMCID: PMC8683083 DOI: 10.7554/eLife.70361

Abstract

Neurodevelopmental axonal pathfinding plays a central role in correct brain wiring and subsequent cognitive abilities. Within the growth cone, various intracellular effectors transduce axonal guidance signals by remodeling the cytoskeleton. Semaphorin-3E (Sema3E) is a guidance cue implicated in development of the fornix, a neuronal tract connecting the hippocampus to the hypothalamus. Microtubule-associated protein 6 (MAP6) has been shown to be involved in the Sema3E growth-promoting signaling pathway. In this study, we identified the collapsin response mediator protein 4 (CRMP4) as a MAP6 partner and a crucial effector in Sema3E growth-promoting activity. CRMP4-KO mice displayed abnormal fornix development reminiscent of that observed in Sema3E-KO mice. CRMP4 was shown to interact with the Sema3E tripartite receptor complex within detergent-

© 2021, Boulan et al.

Keywords: CRMP4; Semaphorin-3E; axonal guidance; collapsin-response-mediator-proteins; detergent-resistant membrane domains; detergent-resistant-membrane-domains; developmental biology; fornix; lipid rafts; neuroscience

Conflict of interest statement

BB, CR, AP, CB, CD, FA, ED, AK, MJ, AF, AA, SG, JD No competing interests declared

References

  1. Nature. 1995 Aug 10;376(6540):509-14 - PubMed
  2. Sci Adv. 2020 Apr 01;6(14):eaaz4344 - PubMed
  3. Cell. 1997 Aug 22;90(4):739-51 - PubMed
  4. J Neurosci. 2008 Feb 27;28(9):2287-97 - PubMed
  5. Mol Cell Endocrinol. 2013 Jul 15;374(1-2):101-7 - PubMed
  6. Biochem Biophys Res Commun. 2003 May 30;305(2):392-9 - PubMed
  7. BMC Cancer. 2010 Nov 24;10:647 - PubMed
  8. J Cell Sci. 2005 Apr 15;118(Pt 8):1687-92 - PubMed
  9. Neuroscience. 2020 May 10;434:83-92 - PubMed
  10. Mech Dev. 2000 May;93(1-2):95-104 - PubMed
  11. J Anat. 2016 May;228(5):792-804 - PubMed
  12. J Biol Chem. 2009 Oct 2;284(40):27393-401 - PubMed
  13. J Neurochem. 2005 Dec;95(6):1629-41 - PubMed
  14. Brain Neurosci Adv. 2017 Aug 4;1(1): - PubMed
  15. EMBO J. 2004 Jan 14;23(1):9-22 - PubMed
  16. J Neurosci. 2007 Feb 14;27(7):1702-11 - PubMed
  17. Brain Res. 2010 Jul 16;1344:209-16 - PubMed
  18. Behav Brain Res. 2006 Nov 11;174(2):251-64 - PubMed
  19. Neuroimage. 2014 Aug 1;96:133-42 - PubMed
  20. Cold Spring Harb Perspect Biol. 2011 Jun 01;3(6): - PubMed
  21. Cold Spring Harb Perspect Biol. 2011 Oct 01;3(10):a004697 - PubMed
  22. Brain Res. 2020 Jun 1;1736:146762 - PubMed
  23. Nat Methods. 2012 Jun 28;9(7):676-82 - PubMed
  24. Neuron. 2004 Apr 8;42(1):51-62 - PubMed
  25. Neuron. 2007 Dec 6;56(5):807-22 - PubMed
  26. Brain Res Bull. 2016 Jun;124:286-94 - PubMed
  27. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1643-8 - PubMed
  28. Proteomics. 2013 Aug;13(16):2419-23 - PubMed
  29. J Biol Chem. 2006 Nov 10;281(45):34009-20 - PubMed
  30. Neurochem Int. 2020 Oct;139:104795 - PubMed
  31. J Biol Chem. 2006 Jun 16;281(24):16591-8 - PubMed
  32. Dev Neurobiol. 2013 Feb;73(2):142-51 - PubMed
  33. PLoS One. 2020 Jul 16;15(7):e0234529 - PubMed
  34. Proteomics. 2012 Apr;12(8):1217-21 - PubMed
  35. Eur J Biochem. 1998 May 15;254(1):14-24 - PubMed
  36. FEBS Lett. 2002 Dec 18;532(3):445-9 - PubMed
  37. Cell Rep. 2014 Nov 20;9(4):1191-201 - PubMed
  38. J Biol Chem. 2005 Dec 30;280(52):42759-65 - PubMed
  39. Nat Commun. 2016 Oct 03;7:12896 - PubMed
  40. J Neurosci. 2007 Nov 14;27(46):12546-54 - PubMed
  41. eNeuro. 2020 Mar 2;7(2): - PubMed
  42. Commun Integr Biol. 2009;2(1):32-4 - PubMed
  43. AIDS Res Hum Retroviruses. 2016 Jan;32(1):68-79 - PubMed
  44. J Neurosci. 2019 Apr 24;39(17):3204-3216 - PubMed
  45. Nat Commun. 2015 Jun 03;6:7246 - PubMed
  46. Blood. 2008 Feb 15;111(4):2290-9 - PubMed
  47. Biochemistry. 1989 Jan 24;28(2):835-42 - PubMed
  48. J Neurosci. 2010 Apr 21;30(16):5635-43 - PubMed
  49. Front Aging Neurosci. 2015 Jan 21;7:1 - PubMed
  50. Mol Biol Cell. 2008 Oct;19(10):4366-73 - PubMed
  51. Neural Plast. 2015;2015:947423 - PubMed
  52. Cold Spring Harb Perspect Biol. 2010 Sep;2(9):a001933 - PubMed
  53. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5813-8 - PubMed
  54. Brain Res. 2017 Jan 15;1655:161-167 - PubMed
  55. Genes Cells. 2005 Feb;10(2):165-79 - PubMed
  56. Mol Neurobiol. 2003 Aug;28(1):51-64 - PubMed
  57. J Neurosci. 2010 Jan 13;30(2):785-96 - PubMed
  58. J Biol Chem. 1995 Jul 21;270(29):17250-6 - PubMed
  59. Nat Cell Biol. 2002 Aug;4(8):583-91 - PubMed
  60. J Biol Chem. 2014 Oct 24;289(43):30133-43 - PubMed
  61. Dev Dyn. 2011 Jan;240(1):9-22 - PubMed
  62. J Biol Chem. 2004 Nov 26;279(48):50176-80 - PubMed
  63. Brain Res. 2008 Sep 10;1229:210-7 - PubMed
  64. Science. 2010 Jan 1;327(5961):46-50 - PubMed
  65. Int J Clin Exp Med. 2014 Jan 15;7(1):67-75 - PubMed
  66. Nat Methods. 2016 Oct;13(10):859-67 - PubMed
  67. J Mol Neurosci. 2015 Feb;55(2):406-15 - PubMed
  68. Front Neuroanat. 2018 Aug 15;12:67 - PubMed
  69. Dev Biol. 2012 Oct 15;370(2):223-36 - PubMed
  70. PLoS One. 2017 Jan 10;12(1):e0169609 - PubMed
  71. Genes Dev. 1999 Dec 1;13(23):3125-35 - PubMed
  72. Mol Psychiatry. 2020 Apr;25(4):883-895 - PubMed
  73. J Neurochem. 2005 Jun;93(6):1371-82 - PubMed
  74. Neuron. 2010 Apr 29;66(2):205-19 - PubMed
  75. J Biophotonics. 2019 Aug;12(8):e201800368 - PubMed
  76. J Cell Biol. 1998 Jul 13;142(1):167-79 - PubMed
  77. Sci Rep. 2017 Dec 1;7(1):16812 - PubMed
  78. Dev Neurobiol. 2012 Nov;72(11):1447-57 - PubMed
  79. Cell. 2014 Nov 6;159(4):896-910 - PubMed
  80. Neuron. 2000 Oct;28(1):41-51 - PubMed
  81. Nat Commun. 2015 Feb 27;6:6366 - PubMed
  82. Biosci Rep. 2007 Dec;27(6):335-58 - PubMed

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