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Zito GA, Tarrano C, Jegatheesan P, et al. Somatotopy of cervical dystonia in motor-cerebellar networks: Evidence from resting state fMRI. Parkinsonism Relat Disord. 2021;94:30-36doi: 10.1016/j.parkreldis.2021.11.034.
Zito, G. A., Tarrano, C., Jegatheesan, P., Ekmen, A., Béranger, B., Rebsamen, M., Hubsch, C., Sangla, S., Bonnet, C., Delorme, C., Méneret, A., Degos, B., Bouquet, F., Brissard, M. A., Vidailhet, M., Gallea, C., Roze, E., & Worbe, Y. (2021). Somatotopy of cervical dystonia in motor-cerebellar networks: Evidence from resting state fMRI. Parkinsonism & related disorders, 9430-36. https://doi.org/10.1016/j.parkreldis.2021.11.034
Zito, Giuseppe A, et al. "Somatotopy of cervical dystonia in motor-cerebellar networks: Evidence from resting state fMRI." Parkinsonism & related disorders vol. 94 (2021): 30-36. doi: https://doi.org/10.1016/j.parkreldis.2021.11.034
Zito GA, Tarrano C, Jegatheesan P, Ekmen A, Béranger B, Rebsamen M, Hubsch C, Sangla S, Bonnet C, Delorme C, Méneret A, Degos B, Bouquet F, Brissard MA, Vidailhet M, Gallea C, Roze E, Worbe Y. Somatotopy of cervical dystonia in motor-cerebellar networks: Evidence from resting state fMRI. Parkinsonism Relat Disord. 2021 Nov 30;94:30-36. doi: 10.1016/j.parkreldis.2021.11.034. Epub 2021 Nov 30. PMID: 34875561.
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Parkinsonism Relat Disord. 2021 Nov 30;94:30-36. doi: 10.1016/j.parkreldis.2021.11.034. Epub 2021 Nov 30.

Somatotopy of cervical dystonia in motor-cerebellar networks: Evidence from resting state fMRI.

Parkinsonism & related disorders

Giuseppe A Zito, Clément Tarrano, Prasanthi Jegatheesan, Asya Ekmen, Benoît Béranger, Michael Rebsamen, Cécile Hubsch, Sophie Sangla, Cécilia Bonnet, Cécile Delorme, Aurélie Méneret, Bertrand Degos, Floriane Bouquet, Marion Apoil Brissard, Marie Vidailhet, Cécile Gallea, Emmanuel Roze, Yulia Worbe

Affiliations

  1. Sorbonne University, Inserm U1127, CNRS UMR7225, UM75, Paris Brain Institute, Movement Investigation and Therapeutics Team, 47-83 Boulevard de l'Hôpital, 75013, Paris, France. Electronic address: [email protected].
  2. Sorbonne University, Inserm U1127, CNRS UMR7225, UM75, Paris Brain Institute, Movement Investigation and Therapeutics Team, 47-83 Boulevard de l'Hôpital, 75013, Paris, France; Department of Neurology, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, 47-83 Boulevard de l'Hôpital, 75013, Paris, France. Electronic address: [email protected].
  3. Sorbonne University, Inserm U1127, CNRS UMR7225, UM75, Paris Brain Institute, Movement Investigation and Therapeutics Team, 47-83 Boulevard de l'Hôpital, 75013, Paris, France. Electronic address: [email protected].
  4. Sorbonne University, Inserm U1127, CNRS UMR7225, UM75, Paris Brain Institute, Movement Investigation and Therapeutics Team, 47-83 Boulevard de l'Hôpital, 75013, Paris, France. Electronic address: [email protected].
  5. Center for NeuroImaging Research CENIR, Paris Brain Institute, Sorbonne University, UPMC Univ Paris 06, Inserm U1127, CNRS UMR 7225, 47-83 Boulevard de l'Hôpital, 75013, Paris, France. Electronic address: [email protected].
  6. Support Center for Advanced Neuroimaging SCAN, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, CH, Switzerland. Electronic address: [email protected].
  7. Department of Neurology, Rothschild Foundation, 25-29 Rue Manin, 75019, Paris, France. Electronic address: [email protected].
  8. Department of Neurology, Rothschild Foundation, 25-29 Rue Manin, 75019, Paris, France. Electronic address: [email protected].
  9. Sorbonne University, Inserm U1127, CNRS UMR7225, UM75, Paris Brain Institute, Movement Investigation and Therapeutics Team, 47-83 Boulevard de l'Hôpital, 75013, Paris, France. Electronic address: [email protected].
  10. Sorbonne University, Inserm U1127, CNRS UMR7225, UM75, Paris Brain Institute, Movement Investigation and Therapeutics Team, 47-83 Boulevard de l'Hôpital, 75013, Paris, France; Department of Neurology, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, 47-83 Boulevard de l'Hôpital, 75013, Paris, France. Electronic address: [email protected].
  11. Sorbonne University, Inserm U1127, CNRS UMR7225, UM75, Paris Brain Institute, Movement Investigation and Therapeutics Team, 47-83 Boulevard de l'Hôpital, 75013, Paris, France; Department of Neurology, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, 47-83 Boulevard de l'Hôpital, 75013, Paris, France. Electronic address: [email protected].
  12. Neurology Unit, Assistance Publique-Hôpitaux de Paris, Avicenne University Hospital, Sorbonne Paris Nord, 125 Rue de Stalingrad, 93000, Bobigny, France; Center for Interdisciplinary Research in Biology, Collège de France, Inserm U1050, CNRS UMR 7241, PSL University, 11 place Marcelin Berthelot, 75231, Paris, France. Electronic address: [email protected].
  13. Department of Neurology, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, 47-83 Boulevard de l'Hôpital, 75013, Paris, France. Electronic address: [email protected].
  14. Department of Neurology, University of Caen Normandie Hospital Center, Av. de la Côte de Nacre, 14000, Caen, France. Electronic address: [email protected].
  15. Sorbonne University, Inserm U1127, CNRS UMR7225, UM75, Paris Brain Institute, Movement Investigation and Therapeutics Team, 47-83 Boulevard de l'Hôpital, 75013, Paris, France; Department of Neurology, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, 47-83 Boulevard de l'Hôpital, 75013, Paris, France. Electronic address: [email protected].
  16. Sorbonne University, Inserm U1127, CNRS UMR7225, UM75, Paris Brain Institute, Movement Investigation and Therapeutics Team, 47-83 Boulevard de l'Hôpital, 75013, Paris, France. Electronic address: [email protected].
  17. Sorbonne University, Inserm U1127, CNRS UMR7225, UM75, Paris Brain Institute, Movement Investigation and Therapeutics Team, 47-83 Boulevard de l'Hôpital, 75013, Paris, France; Department of Neurology, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, 47-83 Boulevard de l'Hôpital, 75013, Paris, France. Electronic address: [email protected].
  18. Sorbonne University, Inserm U1127, CNRS UMR7225, UM75, Paris Brain Institute, Movement Investigation and Therapeutics Team, 47-83 Boulevard de l'Hôpital, 75013, Paris, France; Department of Neurophysiology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris, 184 Rue du Faubourg Saint-Antoine, 75012, Paris, France. Electronic address: [email protected].

PMID: 34875561 DOI: 10.1016/j.parkreldis.2021.11.034

Abstract

INTRODUCTION: Cervical dystonia is the most frequent form of isolated focal dystonia. It is often associated with a dysfunction in brain networks, mostly affecting the basal ganglia, the cerebellum, and the somatosensory cortex. However, it is unclear if such a dysfunction is somato-specific to the brain areas containing the representation of the affected body part, and may thereby account for the focal expression of cervical dystonia. In this study, we investigated resting state functional connectivity in the areas within the motor cortex and the cerebellum containing affected and non-affected body representations in cervical dystonia patients.

METHODS: Eighteen patients affected by cervical dystonia and 21 healthy controls had resting state fMRI. The functional connectivity between the motor cortex and the cerebellum, as well as their corresponding measures of gray matter volume and cortical thickness, were compared between groups. We performed seed-based analyses, selecting the different body representation areas in the precentral gyrus as seed regions, and all cerebellar areas as target regions.

RESULTS: Compared to controls, patients exhibited increased functional connectivity between the bilateral trunk representation area of the motor cortex and the cerebellar vermis 6 and 7b, respectively. These functional abnormalities did not correlate with structural changes or symptom severity.

CONCLUSIONS: Our findings indicate that the abnormal function of the motor network is somato-specific to the areas encompassing the neck representation. Functional abnormalities in discrete relevant areas of the motor network could thus contribute to the focal expression of CD.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Cerebellum; Cervical dystonia; Motor cortex; Resting state fMRI

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