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Circ Res. 2021 Nov 12;129(11):1054-1066. doi: 10.1161/CIRCRESAHA.121.318982. Epub 2021 Oct 04.

Laminar Flow on Endothelial Cells Suppresses eNOS O-GlcNAcylation to Promote eNOS Activity.

Circulation research

Sarah E Basehore, Samantha Bohlman, Callie Weber, Swathi Swaminathan, Yuji Zhang, Cholsoon Jang, Zoltan Arany, Alisa Morss Clyne

Affiliations

  1. School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA (S.E.B., S.S.).
  2. Fischell Department of Biomedical Engineering, College of Engineering, University of Maryland, College Park (S.B., C.W., A.M.C.).
  3. Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore (Y.Z.).
  4. Biological Chemistry, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine (C.J.).
  5. Perelman School of Medicine, University of Pennsylvania, Philadelphia (Z.A.).

PMID: 34605247 PMCID: PMC8653916 DOI: 10.1161/CIRCRESAHA.121.318982

Abstract

[Figure: see text].

Keywords: acetylglucosamine; cardiovascular diseases; endothelial cells; glycolysis; hemodynamics; hexosamines; nitric oxide

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