J Clin Endocrinol Metab. 2021 Nov 20; doi: 10.1210/clinem/dgab845. Epub 2021 Nov 20.
Lower Circulating Sertoli and Leydig Cell Hormone Levels During Puberty in Obese Boys: A Cross-sectional Study.
The Journal of clinical endocrinology and metabolism
Solene Rerat, Jessica Amsellem-Jager, Marie Clemence L'hour, Natacha Bouhours-Nouet, Aurelie Donzeau, Stephanie Rouleau, Lucie Levaillant, Fabienne Emeriau, Valerie Moal, Florence Boux de Casson, Najiba Lahlou, Regis Coutant
Affiliations
Affiliations
- Department of Pediatric Endocrinology, University Hospital, 49000 Angers, France.
- Reference Center for Rare Pituitary Diseases, University Hospital, 49000 Angers, France.
- Department of Pediatrics, General Hospital, 56100 Lorient, France.
- Department of Hormonology, University Hospital, 49000 Angers, France.
- Department of Hormonology, BPR Specialized Analyses, 45700 Pannes, France.
PMID: 34918072
DOI: 10.1210/clinem/dgab845
Abstract
CONTEXT: Alterations in semen characteristics and circulating Sertoli and Leydig cell hormones have been described in obese male adults. Whether hormonal alterations occur before adulthood has not been fully evaluated.
OBJECTIVE: We describe circulating Sertoli and Leydig cell hormone levels in overweight-obese (ow/ob) boys through childhood and adolescence in a cross-sectional study.
METHODS: Monocentric study in the Pediatric Endocrinology Unit of Angers University Hospital. Three hundred and fifty-one obese and overweight boys aged 5-19 years underwent physical examination, dual-energy X-ray absorptiometry for body composition, oral glucose tolerance test on insulin and glucose, and measurements of follicle-stimulating hormone, luteinizing hormone, anti-Müllerian hormone (AMH), inhibin B, testosterone, and estradiol. Hormonal levels were compared with normative data obtained from 652 healthy nonoverweight nonobese boys of similar age or Tanner stage.
RESULTS: Median inhibin B and testosterone levels during puberty were significantly lower in ow/ob than in healthy boys (1) from age >12 years and thereafter for inhibin B, and (2) from age >14 years and thereafter for testosterone. At Tanner stages 4 and 5, 26%, 31%, and 18% of inhibin B, testosterone, and AMH values were below the 5th percentile in ow/ob subjects (P < .01). In multiple regression analyses, estradiol and total bone mineral density Z-score were negative predictors of inhibin B, fat mass percentage was a negative predictor of testosterone, and insulin was a negative predictor of AMH.
CONCLUSION: Lower Sertoli and Leydig cell hormone levels during puberty were observed in the ow/ob boys.
© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: [email protected].
Keywords: anti-Müllerian hormone; inhibin B; male; obese; puberty; testosterone
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