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Front Pharmacol. 2021 Dec 01;12:758962. doi: 10.3389/fphar.2021.758962. eCollection 2021.

Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway.

Frontiers in pharmacology

Ji Hu, Ru Chen, Jie An, Yilong Wang, Minglu Liang, Kai Huang

Affiliations

  1. Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  2. Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  3. Department of Cardiology, Handan First Hospital, Handan, China.
  4. Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

PMID: 34925018 PMCID: PMC8672219 DOI: 10.3389/fphar.2021.758962

Abstract

Endothelial cells are the fundamental components of blood vessels that regulate several physiological processes including immune responses, angiogenesis, and vascular tone. Endothelial dysfunction contributes to the development of various diseases such as acute lung injury, and endothelial inflammation is a vital part of endothelial dysfunction. Dauricine is an extract isolated from

Copyright © 2021 Hu, Chen, An, Wang, Liang and Huang.

Keywords: NF-κB pathway; acute lung injury; dauricine; endothelial dysfunction; inflammation

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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