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Sarmento MJ, Owen MC, Ricardo JC, et al. The impact of the glycan headgroup on the nanoscopic segregation of gangliosides. Biophys J. 2021;120(24):5530-5543doi: 10.1016/j.bpj.2021.11.017.
Sarmento, M. J., Owen, M. C., Ricardo, J. C., Chmelová, B., Davidović, D., Mikhalyov, I., Gretskaya, N., Hof, M., Amaro, M., Vácha, R., & Šachl, R. (2021). The impact of the glycan headgroup on the nanoscopic segregation of gangliosides. Biophysical journal, 120(24), 5530-5543. https://doi.org/10.1016/j.bpj.2021.11.017
Sarmento, Maria J, et al. "The impact of the glycan headgroup on the nanoscopic segregation of gangliosides." Biophysical journal vol. 120,24 (2021): 5530-5543. doi: https://doi.org/10.1016/j.bpj.2021.11.017
Sarmento MJ, Owen MC, Ricardo JC, Chmelová B, Davidović D, Mikhalyov I, Gretskaya N, Hof M, Amaro M, Vácha R, Šachl R. The impact of the glycan headgroup on the nanoscopic segregation of gangliosides. Biophys J. 2021 Dec 21;120(24):5530-5543. doi: 10.1016/j.bpj.2021.11.017. Epub 2021 Nov 17. PMID: 34798138.
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Biophys J. 2021 Dec 21;120(24):5530-5543. doi: 10.1016/j.bpj.2021.11.017. Epub 2021 Nov 17.

The impact of the glycan headgroup on the nanoscopic segregation of gangliosides.

Biophysical journal

Maria J Sarmento, Michael C Owen, Joana C Ricardo, Barbora Chmelová, David Davidović, Ilya Mikhalyov, Natalia Gretskaya, Martin Hof, Mariana Amaro, Robert Vácha, Radek Šachl

Affiliations

  1. J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Prague, Czech Republic.
  2. CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic; Institute of Chemistry, Faculty of Materials Science and Engineering, University of Miskolc, 3515 Miskolc, Hungary.
  3. J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic.
  4. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science, Moscow Ul. Miklukho-Maklaya, Moscow 117997, Russia.
  5. CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
  6. J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Prague, Czech Republic. Electronic address: [email protected].

PMID: 34798138 DOI: 10.1016/j.bpj.2021.11.017

Abstract

Gangliosides form an important class of receptor lipids containing a large oligosaccharide headgroup whose ability to self-organize within lipid membranes results in the formation of nanoscopic platforms. Despite their biological importance, the molecular basis for the nanoscopic segregation of gangliosides is not clear. In this work, we investigated the role of the ganglioside headgroup on the nanoscale organization of gangliosides. We studied the effect of the reduction in the number of sugar units of the ganglioside oligosaccharide chain on the ability of gangliosides GM

Copyright © 2021 Biophysical Society. Published by Elsevier Inc. All rights reserved.

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