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Sangnes DA, Lundervold K, Bekkelund M, et al. Gastrointestinal transit and contractility in diabetic constipation: A wireless motility capsule study on diabetes patients and healthy controls. United European Gastroenterol J. 2021;9(10):1168-1177doi: 10.1002/ueg2.12169.
Sangnes, D. A., Lundervold, K., Bekkelund, M., von Volkmann, H. L., Berentsen, B., Gilja, O. H., Dimcevski, G., & Søfteland, E. (2021). Gastrointestinal transit and contractility in diabetic constipation: A wireless motility capsule study on diabetes patients and healthy controls. United European gastroenterology journal, 9(10), 1168-1177. https://doi.org/10.1002/ueg2.12169
Sangnes, Dag A, et al. "Gastrointestinal transit and contractility in diabetic constipation: A wireless motility capsule study on diabetes patients and healthy controls." United European gastroenterology journal vol. 9,10 (2021): 1168-1177. doi: https://doi.org/10.1002/ueg2.12169
Sangnes DA, Lundervold K, Bekkelund M, von Volkmann HL, Berentsen B, Gilja OH, Dimcevski G, Søfteland E. Gastrointestinal transit and contractility in diabetic constipation: A wireless motility capsule study on diabetes patients and healthy controls. United European Gastroenterol J. 2021 Dec;9(10):1168-1177. doi: 10.1002/ueg2.12169. Epub 2021 Oct 23. PMID: 34687494; PMCID: PMC8672085.
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United European Gastroenterol J. 2021 Dec;9(10):1168-1177. doi: 10.1002/ueg2.12169. Epub 2021 Oct 23.

Gastrointestinal transit and contractility in diabetic constipation: A wireless motility capsule study on diabetes patients and healthy controls.

United European gastroenterology journal

Dag A Sangnes, Katarina Lundervold, Mattis Bekkelund, Hilde L von Volkmann, Birgitte Berentsen, Odd Helge Gilja, Georg Dimcevski, Eirik Søfteland

Affiliations

  1. Department of Medicine, Haukeland University Hospital, Bergen, Norway.
  2. Department of Clinical Medicine, University of Bergen, Bergen, Norway.
  3. The National Centre for Functional Gastrointestinal Disorders, Haukeland University Hospital, Bergen, Norway.
  4. National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway.
  5. Department of Neurology, Haukeland University Hospital, Bergen, Norway.
  6. Department of Clinical Medicine, University of Oslo, Oslo, Norway.
  7. Department of Clinical Science, University of Bergen, Bergen, Norway.
  8. Hormone Laboratory, Haukeland University Hospital, Bergen, Norway.

PMID: 34687494 PMCID: PMC8672085 DOI: 10.1002/ueg2.12169

Abstract

BACKGROUND: Diabetic constipation is traditionally attributed to slow colonic transit, despite limited evidence. More than half of patients find treatment unsatisfactory. To improve treatment, there is a need for better diagnostic understanding of the condition.

OBJECTIVE: In this wireless motility capsule study, we aimed to investigate gastrointestinal transit and contractility in diabetes patients with and without constipation, and in healthy controls.

METHODS: We prospectively included type 1 or type 2 diabetes patients with gastrointestinal symptoms. Based on the Gastrointestinal Symptom Rating Scale we distinguished into two groups: with constipation and without constipation. Non-diabetic controls were asymptomatic. All were examined with wireless motility capsule, determining transit times and contractility parameters.

RESULTS: 57 patients (42 women, 46 with type 1 diabetes) and 26 healthy controls (14 women) were included. We found no difference in transit times between diabetes patients with and without constipation. Compared to healthy controls (35:55, h:min), whole-gut transit was slower in both diabetes patients with constipation (66:15, p = 0.03) and without constipation (71:16, p < 0.001). Small bowel motility index correlated r

CONCLUSIONS: Diabetes patients with constipation had similar transit times as those without constipation. Both groups had slower whole-gut transit than healthy controls. Constipation was associated with reduced small bowel, but not colonic contractility. Our results imply that other mechanisms than slow colonic transit may be more important in the pathogenesis of diabetic constipation.

© 2021 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.

Keywords: constipation; diabetes mellitus; gastroenteropathy; motility; transit; wireless motility capsule

References

  1. Am J Gastroenterol. 2019 Jan;114(1):135-142 - PubMed
  2. Dig Dis Sci. 1993 Jan;38(1):45-50 - PubMed
  3. Diabetes Care. 2018 Mar;41(3):627-637 - PubMed
  4. PLoS One. 2017 Sep 28;12(9):e0185496 - PubMed
  5. Aliment Pharmacol Ther. 2007 Mar 1;25(5):599-608 - PubMed
  6. Clin Gastroenterol Hepatol. 2020 Oct 28;: - PubMed
  7. Gastroenterology. 2021 May;160(6):2006-2017 - PubMed
  8. Am J Gastroenterol. 2021 Apr;116(4):758-768 - PubMed
  9. J Intern Med. 2021 Dec;290(6):1206-1218 - PubMed
  10. Am J Physiol Gastrointest Liver Physiol. 2009 Dec;297(6):G1107-14 - PubMed
  11. J Gastroenterol Hepatol. 2018 Apr;33(4):863-868 - PubMed
  12. Aliment Pharmacol Ther. 2015 Sep;42(6):761-72 - PubMed
  13. Dig Dis Sci. 2012 Jun;57(6):1445-64 - PubMed
  14. J Diabetes Complications. 2018 Jan;32(1):89-94 - PubMed
  15. Scand J Gastroenterol. 1995 Nov;30(11):1046-52 - PubMed
  16. Neurogastroenterol Motil. 2011 Jan;23(1):8-23 - PubMed
  17. Clin Gastroenterol Hepatol. 2020 Oct;18(11):2479-2490 - PubMed
  18. J Neurogastroenterol Motil. 2019 Apr 30;25(2):267-275 - PubMed
  19. Neurogastroenterol Motil. 2020 Apr;32(4):e13771 - PubMed
  20. J Clin Med. 2021 Jan 22;10(3): - PubMed
  21. Dig Dis Sci. 1998 Nov;43(11):2373-8 - PubMed
  22. Neurogastroenterol Motil. 2008 Jun;20(6):635-42 - PubMed
  23. Diabetes Res Clin Pract. 2012 May;96(2):248-55 - PubMed
  24. Acta Psychiatr Scand. 1983 Jun;67(6):361-70 - PubMed
  25. Therap Adv Gastroenterol. 2019 Jun 17;12:1756284819852047 - PubMed
  26. Neurogastroenterol Motil. 2017 Sep;29(9): - PubMed
  27. United European Gastroenterol J. 2017 Jun;5(4):465-472 - PubMed
  28. PLoS One. 2015 Oct 28;10(10):e0141183 - PubMed
  29. Gastroenterology. 1997 Jul;113(1):60-6 - PubMed
  30. Dig Dis Sci. 2015 May;60(5):1350-7 - PubMed
  31. Dig Dis. 1990;8(1):23-36 - PubMed
  32. Yonsei Med J. 2003 Apr 30;44(2):265-72 - PubMed
  33. Aliment Pharmacol Ther. 2018 Feb;47(3):391-400 - PubMed
  34. United European Gastroenterol J. 2021 Dec;9(10):1168-1177 - PubMed
  35. Neurogastroenterol Motil. 2008 Dec;20(12):1269-82 - PubMed

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