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Pedrianes-Martin PB, Martin-Rincon M, Morales-Alamo D, et al. Treatment of hypertension with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and resting metabolic rate: A cross-sectional study. J Clin Hypertens (Greenwich). 2021;23(12):2106-2114doi: 10.1111/jch.14392.
Pedrianes-Martin, P. B., Martin-Rincon, M., Morales-Alamo, D., Perez-Suarez, I., Perez-Valera, M., Galvan-Alvarez, V., Curtelin, D., de Pablos-Velasco, P., & Calbet, J. A. L. (2021). Treatment of hypertension with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and resting metabolic rate: A cross-sectional study. Journal of clinical hypertension (Greenwich, Conn.), 23(12), 2106-2114. https://doi.org/10.1111/jch.14392
Pedrianes-Martin, Pablo B, et al. "Treatment of hypertension with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and resting metabolic rate: A cross-sectional study." Journal of clinical hypertension (Greenwich, Conn.) vol. 23,12 (2021): 2106-2114. doi: https://doi.org/10.1111/jch.14392
Pedrianes-Martin PB, Martin-Rincon M, Morales-Alamo D, Perez-Suarez I, Perez-Valera M, Galvan-Alvarez V, Curtelin D, de Pablos-Velasco P, Calbet JAL. Treatment of hypertension with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and resting metabolic rate: A cross-sectional study. J Clin Hypertens (Greenwich). 2021 Dec;23(12):2106-2114. doi: 10.1111/jch.14392. Epub 2021 Nov 30. PMID: 34846787.
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J Clin Hypertens (Greenwich). 2021 Dec;23(12):2106-2114. doi: 10.1111/jch.14392. Epub 2021 Nov 30.

Treatment of hypertension with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and resting metabolic rate: A cross-sectional study.

Journal of clinical hypertension (Greenwich, Conn.)

Pablo B Pedrianes-Martin, Marcos Martin-Rincon, David Morales-Alamo, Ismael Perez-Suarez, Mario Perez-Valera, Victor Galvan-Alvarez, David Curtelin, Pedro de Pablos-Velasco, Jose A L Calbet

Affiliations

  1. Department of Endocrinology and Nutrition, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain.
  2. Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain.
  3. Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain.
  4. Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.

PMID: 34846787 DOI: 10.1111/jch.14392

Abstract

Hypertension in obese and overweight patients is associated with an elevated resting metabolic rate (RMR). The aim of this study was to determine whether RMR is reduced in hypertensive patients treated with angiotensin-converting enzyme inhibitors (ACEI) and blockers (ARB). The RMR was determined by indirect calorimetry in 174 volunteers; 93 (46.5 %) were hypertensive, of which 16 men and 13 women were treated with ACEI/ARB, while 30 men and 19 women with untreated hypertension served as a control group. Treated and untreated hypertensives had similar age, BMI, physical activity, and cardiorespiratory fitness. The RMR normalized to the lean body mass (LBM) was 15% higher in the untreated than ACEI/ARB-treated hypertensive women (p = .003). After accounting for LBM, whole-body fat mass, age, the double product (heart rate x systolic blood pressure), and the distance walked per day, the RMR was 2.9% lower in the patients taking ACEI/ARB (p = .26, treatment x sex interaction p = .005). LBM, age, and the double product explained 78% of the variability in RMR (R

© 2021 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC.

Keywords: angiotensin; exercise; obesity; overweight; resting energy expenditure; women

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