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Kim JS, Axelsson GT, Moll M, et al. Associations of Monocyte Count and Other Immune Cell Types with Interstitial Lung Abnormalities. Am J Respir Crit Care Med. 2021;doi: 10.1164/rccm.202108-1967OC.
Kim, J. S., Axelsson, G. T., Moll, M., Anderson, M. R., Bernstein, E. J., Putman, R. K., Hida, T., Hatabu, H., Hoffman, E. A., Raghu, G., Kawut, S. M., Doyle, M. F., Tracy, R., Launer, L. J., Manichaikul, A., Rich, S. S., Lederer, D. J., Gudnason, V., Hobbs, B. D., Cho, M. H., Hunninghake, G. M., Garcia, C. K., Gudmundsson, G., Barr, R. G., & Podolanczuk, A. J. (2021). Associations of Monocyte Count and Other Immune Cell Types with Interstitial Lung Abnormalities. American journal of respiratory and critical care medicine, . https://doi.org/10.1164/rccm.202108-1967OC
Kim, John S, et al. "Associations of Monocyte Count and Other Immune Cell Types with Interstitial Lung Abnormalities." American journal of respiratory and critical care medicine vol. (2021). doi: https://doi.org/10.1164/rccm.202108-1967OC
Kim JS, Axelsson GT, Moll M, Anderson MR, Bernstein EJ, Putman RK, Hida T, Hatabu H, Hoffman EA, Raghu G, Kawut SM, Doyle MF, Tracy R, Launer LJ, Manichaikul A, Rich SS, Lederer DJ, Gudnason V, Hobbs BD, Cho MH, Hunninghake GM, Garcia CK, Gudmundsson G, Barr RG, Podolanczuk AJ. Associations of Monocyte Count and Other Immune Cell Types with Interstitial Lung Abnormalities. Am J Respir Crit Care Med. 2021 Dec 20; doi: 10.1164/rccm.202108-1967OC. Epub 2021 Dec 20. PMID: 34929108.
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Am J Respir Crit Care Med. 2021 Dec 20; doi: 10.1164/rccm.202108-1967OC. Epub 2021 Dec 20.

Associations of Monocyte Count and Other Immune Cell Types with Interstitial Lung Abnormalities.

American journal of respiratory and critical care medicine

John S Kim, Gísli Thor Axelsson, Matthew Moll, Michaela R Anderson, Elana J Bernstein, Rachel K Putman, Tomoyuki Hida, Hiroto Hatabu, Eric A Hoffman, Ganesh Raghu, Steven M Kawut, Margaret F Doyle, Russell Tracy, Lenore J Launer, Ani Manichaikul, Stephen S Rich, David J Lederer, Vilmundur Gudnason, Brian D Hobbs, Michael H Cho, Gary M Hunninghake, Christine Kim Garcia, Gunnar Gudmundsson, R Graham Barr, Anna J Podolanczuk

Affiliations

  1. Columbia University, Medicine, New York, New York, United States.
  2. University of Virginia, Medicine, Charlottesville, Virginia, United States; [email protected].
  3. University of Iceland, Reykjavik, Iceland.
  4. Icelandic Heart Association, 64395, Kopavogur, Iceland.
  5. Brigham and Women's Hospital Department of Medicine, 370908, Pulmonary and Critical Care, Boston, Massachusetts, United States.
  6. Columbia University Medical Center, Medicine, NYC, New York, United States.
  7. Columbia University Medical Center, New York, New York, United States.
  8. Brigham and Women's Hospital, 1861, Pulmonary and Critical Care Medicine, Boston, Massachusetts, United States.
  9. Kyushu University, 12923, Clinical Radiology, Fukuoka, Japan.
  10. Brigham and Women's Hospital, 1861, Department of Radiology, Boston, Massachusetts, United States.
  11. University of Iowa Carver College of Medicine, Radiology, Iowa City, Iowa, United States.
  12. University of Washington Medical Center, 21617, Division of Pulmonary and Critical Care Medicine, Seattle, Washington, United States.
  13. University of Pennsylvania Perelman School of Medicine, 14640, Medicine , Philadelphia, Pennsylvania, United States.
  14. University of Vermont College of Arts and Sciences, 173134, Burlington, Vermont, United States.
  15. University of Vermont, Pathology, 05446, Vermont, United States.
  16. National Institute on Aging Intramural Research Program, 171247, Baltimore, Maryland, United States.
  17. University of Virginia Center for Public Health Genomics, 214843, Charlottesville, Virginia, United States.
  18. University of Virginia, Center for Public Health Genomics, Charlottesville, Virginia, United States.
  19. Regeneron Pharmaceuticals Inc, 7845, Tarrytown, New York, United States.
  20. Columbia University Medical Center, 21611, New York, New York, United States.
  21. Hjartavernd, 64395, Kopavogur, Iceland.
  22. Brigham and Women's Hospital Channing Division of Network Medicine, 1869, Boston, Massachusetts, United States.
  23. Harvard Medical School, Channing Division of Respiratory Medicine, Boston, Massachusetts, United States.
  24. Brigham and Women\'s Hospital, 1861, Medicine, Boston, Massachusetts, United States.
  25. UT Southwestern Medical, McDermott Center, Dallas, Texas, United States.
  26. Columbia University Medical Center, 21611, Internal Medicine, New York, New York, United States.
  27. Landspitali University Hospital, Respiratory Medicine, Sleep and Allergy, Reykjavik, Iceland.
  28. Columbia University, Epidemiology, New York, New York, United States.
  29. Weill Cornell Medical College, 12295, Department of Medicine, New York, New York, United States.

PMID: 34929108 DOI: 10.1164/rccm.202108-1967OC

Abstract

RATIONALE: Higher blood monocyte counts are associated with worse survival in adults with clinically diagnosed pulmonary fibrosis. Their association with the development and progression of interstitial lung abnormalities (ILA) in humans is unknown.

OBJECTIVES: We evaluated the associations of blood monocyte count, and other immune cell types, with ILA, high attenuation areas (HAA), and forced vital capacity (FVC) in four independent cohorts.

METHODS: We included participants with measured monocyte counts and CT imaging enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA, n=484), Age/Gene Environment Susceptibility Study (AGES-Reykjavik, n=3,547), Genetic Epidemiology of COPD (COPDGene, n=2,719), and the Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE, n=646).

MEASUREMENTS AND MAIN RESULTS: After adjustment for covariates, a 1-SD increment in blood monocyte count was associated with ILA in MESA (odds ratio (OR) 1.3, 95% CI 1.0-1.8), AGES-Reykjavik (OR 1.2, 95% CI 1.1-1.3), COPDGene (OR 1.3, 95% CI 1.2-1.4), and ECLIPSE (OR 1.2, 95% CI 1.0-1.4). A higher monocyte count was associated with ILA progression over 5 years in AGES-Reykjavik (OR 1.2, 95% CI 1.0-1.3). Compared with participants without ILA, there was a higher percentage of activated monocytes among those with ILA in MESA. Higher monocyte count was associated with greater HAA in MESA and lower FVC in MESA and COPDGene. Associations of other immune cell types were less consistent.

CONCLUSIONS: Higher blood monocyte counts were associated with the presence and progression of interstitial lung abnormalities and lower FVC.

Keywords: immunity; interstitial lung abnormalities; monocyte

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