Display options
Cite
Delval A, Girard B, Lacan L, et al. Neurophysiological recordings improve the accuracy of the evaluation of the outcome in perinatal hypoxic ischemic encephalopathy. Eur J Paediatr Neurol. 2021;36:51-56doi: 10.1016/j.ejpn.2021.11.010.
Delval, A., Girard, B., Lacan, L., Chaton, L., Flamein, F., Storme, L., Derambure, P., The Tich, S. N., Lamblin, M. D., & Betrouni, N. (2021). Neurophysiological recordings improve the accuracy of the evaluation of the outcome in perinatal hypoxic ischemic encephalopathy. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 3651-56. https://doi.org/10.1016/j.ejpn.2021.11.010
Delval, Arnaud, et al. "Neurophysiological recordings improve the accuracy of the evaluation of the outcome in perinatal hypoxic ischemic encephalopathy." European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society vol. 36 (2021): 51-56. doi: https://doi.org/10.1016/j.ejpn.2021.11.010
Delval A, Girard B, Lacan L, Chaton L, Flamein F, Storme L, Derambure P, The Tich SN, Lamblin MD, Betrouni N. Neurophysiological recordings improve the accuracy of the evaluation of the outcome in perinatal hypoxic ischemic encephalopathy. Eur J Paediatr Neurol. 2021 Dec 03;36:51-56. doi: 10.1016/j.ejpn.2021.11.010. Epub 2021 Dec 03. PMID: 34890946.
Copy Download .nbib Format: NLM
Share it on

Eur J Paediatr Neurol. 2021 Dec 03;36:51-56. doi: 10.1016/j.ejpn.2021.11.010. Epub 2021 Dec 03.

Neurophysiological recordings improve the accuracy of the evaluation of the outcome in perinatal hypoxic ischemic encephalopathy.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

Arnaud Delval, Barbara Girard, Laure Lacan, Laurence Chaton, Florence Flamein, Laurent Storme, Philippe Derambure, Sylvie Nguyen The Tich, Marie-Dominique Lamblin, Nacim Betrouni

Affiliations

  1. Univ. Lille, Inserm, U1172 - Lille, Neuroscience Cognition, F-59000, Lille, France; Clinical Neurophysiology Department, Lille University Medical Center, F-59000, Lille, France. Electronic address: [email protected].
  2. Children Department of Physical Medicine and Rehabilitation, Institut Régional de Réadaptation, Flavigny sur Moselle, France.
  3. EA4489, Environnement Périnatal et Santé, Faculté de Médecine, Université de Lille, France; Pediatric Neurology Department, Lille University Medical Center, F-59000, Lille, France.
  4. Clinical Neurophysiology Department, Lille University Medical Center, F-59000, Lille, France.
  5. EA4489, Environnement Périnatal et Santé, Faculté de Médecine, Université de Lille, France.
  6. Pediatric Neurology Department, Lille University Medical Center, F-59000, Lille, France.
  7. Univ. Lille, Inserm, U1172 - Lille, Neuroscience Cognition, F-59000, Lille, France; Clinical Neurophysiology Department, Lille University Medical Center, F-59000, Lille, France.
  8. Univ. Lille, Inserm, U1172 - Lille, Neuroscience Cognition, F-59000, Lille, France.

PMID: 34890946 DOI: 10.1016/j.ejpn.2021.11.010

Abstract

OBJECTIVES: Our objective was to evaluate the potential additional value of electroencephalogram (EEG) and evoked potentials in neonates with hypoxic-ischemic encephalopathy to predict their disability at 1 and 2 years old.

METHODS: 30 full-term infants after perinatal asphyxia who underwent therapeutic hypothermia were evaluated at 1 year and 2 years for disability using International Classification of Functioning, Disability and Health classification. Scores for EEG, sensory evoked potentials and brainstem auditory evoked potentials were evaluated after withdrawal of therapeutic hypothermia that lasted 72 h. A regression approach was investigated to build models allowing to distinguish neonates according to their disability at 1 and 2 years. Two models were built, the first by considering the clinical data and EEG before and after therapeutic hypothermia and the second by incorporating evoked potentials recording.

RESULTS: Adding EEG and evoked potentials data after rewarming improved dramatically the accuracy of the model considering outcome at 1 and 2 years.

INTERPRETATION: We propose to record systematically EEG and evoked potentials following rewarming to predict the outcome of neonates with hypoxic ischemic encephalopathy. Combination of altered evoked potentials with no improvement of EEG after rewarming appeared to be a robust criterion for a poor outcome.

Copyright © 2021. Published by Elsevier Ltd.

Keywords: Evoked potentials; Hypoxic ischemic encephalopathy; Neonatal EEG; Perinatal asphyxia

Publication Types