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Silvério D, Gonçalves R, Appelberg R, et al. Advances on the Role and Applications of Interleukin-1 in Tuberculosis. mBio. 2021;12(6):e0313421doi: 10.1128/mBio.03134-21.
Silvério, D., Gonçalves, R., Appelberg, R., & Saraiva, M. (2021). Advances on the Role and Applications of Interleukin-1 in Tuberculosis. mBio, 12(6), e0313421. https://doi.org/10.1128/mBio.03134-21
Silvério, Diogo, et al. "Advances on the Role and Applications of Interleukin-1 in Tuberculosis." mBio vol. 12,6 (2021): e0313421. doi: https://doi.org/10.1128/mBio.03134-21
Silvério D, Gonçalves R, Appelberg R, Saraiva M. Advances on the Role and Applications of Interleukin-1 in Tuberculosis. mBio. 2021 Dec 21;12(6):e0313421. doi: 10.1128/mBio.03134-21. Epub 2021 Nov 23. PMID: 34809460; PMCID: PMC8609357.
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mBio. 2021 Dec 21;12(6):e0313421. doi: 10.1128/mBio.03134-21. Epub 2021 Nov 23.

Advances on the Role and Applications of Interleukin-1 in Tuberculosis.

mBio

Diogo Silvério, Rute Gonçalves, Rui Appelberg, Margarida Saraiva

Affiliations

  1. i3S-Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.
  2. IBMC-Instituto de Biologia Molecular e Celular, University of Porto, Porto, Portugal.
  3. Doctoral Program in Molecular and Cell Biology, ICBAS-Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal.
  4. Master's Program in Cell and Molecular Biology, FCUP-Faculdade de Ciências, University of Porto, Porto, Portugal.
  5. ICBAS-Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal.

PMID: 34809460 PMCID: PMC8609357 DOI: 10.1128/mBio.03134-21

Abstract

Interleukin-1 (IL-1) is a key player in the immune response to pathogens due to its role in promoting inflammation and recruiting immune cells to the site of infection. In tuberculosis (TB), tight regulation of IL-1 responses is critical to ensure host resistance to infection while preventing immune pathology. In the mouse model of Mycobacterium tuberculosis infection, both IL-1 absence and overproduction result in exacerbated disease and mortality. In humans, several polymorphisms in the

Keywords: host-pathogen interactions; immune response; infectious disease; interleukins; tuberculosis

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