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Yang NJ, Isensee J, Neel DV, et al. Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2. Nat Neurosci. 2021;doi: 10.1038/s41593-021-00973-8.
Yang, N. J., Isensee, J., Neel, D. V., Quadros, A. U., Zhang, H. B., Lauzadis, J., Liu, S. M., Shiers, S., Belu, A., Palan, S., Marlin, S., Maignel, J., Kennedy-Curran, A., Tong, V. S., Moayeri, M., Röderer, P., Nitzsche, A., Lu, M., Pentelute, B. L., Brüstle, O., Tripathi, V., Foster, K. A., Price, T. J., Collier, R. J., Leppla, S. H., Puopolo, M., Bean, B. P., Cunha, T. M., Hucho, T., & Chiu, I. M. (2021). Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2. Nature neuroscience, . https://doi.org/10.1038/s41593-021-00973-8
Yang, Nicole J, et al. "Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2." Nature neuroscience vol. (2021). doi: https://doi.org/10.1038/s41593-021-00973-8
Yang NJ, Isensee J, Neel DV, Quadros AU, Zhang HB, Lauzadis J, Liu SM, Shiers S, Belu A, Palan S, Marlin S, Maignel J, Kennedy-Curran A, Tong VS, Moayeri M, Röderer P, Nitzsche A, Lu M, Pentelute BL, Brüstle O, Tripathi V, Foster KA, Price TJ, Collier RJ, Leppla SH, Puopolo M, Bean BP, Cunha TM, Hucho T, Chiu IM. Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2. Nat Neurosci. 2021 Dec 20; doi: 10.1038/s41593-021-00973-8. Epub 2021 Dec 20. PMID: 34931070.
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Nat Neurosci. 2021 Dec 20; doi: 10.1038/s41593-021-00973-8. Epub 2021 Dec 20.

Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2.

Nature neuroscience

Nicole J Yang, Jörg Isensee, Dylan V Neel, Andreza U Quadros, Han-Xiong Bear Zhang, Justas Lauzadis, Sai Man Liu, Stephanie Shiers, Andreea Belu, Shilpa Palan, Sandra Marlin, Jacquie Maignel, Angela Kennedy-Curran, Victoria S Tong, Mahtab Moayeri, Pascal Röderer, Anja Nitzsche, Mike Lu, Bradley L Pentelute, Oliver Brüstle, Vineeta Tripathi, Keith A Foster, Theodore J Price, R John Collier, Stephen H Leppla, Michelino Puopolo, Bruce P Bean, Thiago M Cunha, Tim Hucho, Isaac M Chiu

Affiliations

  1. Department of Immunology, Harvard Medical School, Boston, MA, USA.
  2. Translational Pain Research, Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  3. Center for Research in Inflammatory Diseases, Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  4. Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
  5. Department of Anesthesiology, Stony Brook Medicine, Stony Brook, NY, USA.
  6. Ipsen Bioinnovation Ltd, Abingdon, UK.
  7. Department of Neuroscience, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
  8. Ipsen Innovation, Les Ulis, France.
  9. Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  10. Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty and University Hospital Bonn, Bonn, Germany.
  11. Cellomics Unit, LIFE & BRAIN GmbH, Bonn, Germany.
  12. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
  13. The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  14. Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  15. Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
  16. Department of Microbiology, Harvard Medical School, Boston, MA, USA.
  17. Department of Immunology, Harvard Medical School, Boston, MA, USA. [email protected].

PMID: 34931070 DOI: 10.1038/s41593-021-00973-8

Abstract

Bacterial products can act on neurons to alter signaling and function. In the present study, we found that dorsal root ganglion (DRG) sensory neurons are enriched for ANTXR2, the high-affinity receptor for anthrax toxins. Anthrax toxins are composed of protective antigen (PA), which binds to ANTXR2, and the protein cargoes edema factor (EF) and lethal factor (LF). Intrathecal administration of edema toxin (ET (PA + EF)) targeted DRG neurons and induced analgesia in mice. ET inhibited mechanical and thermal sensation, and pain caused by formalin, carrageenan or nerve injury. Analgesia depended on ANTXR2 expressed by Na

© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.

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