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Lorente L, Martín MM, Pérez-Cejas A, et al. Mortality prediction of patients with spontaneous intracerebral hemorrhage by serum soluble Fas ligand concentrations. Expert Rev Mol Diagn. 2021;1-6doi: 10.1080/14737159.2022.2017775.
Lorente, L., Martín, M. M., Pérez-Cejas, A., González-Rivero, A. F., Ramos-Gómez, L., Solé-Violán, J., Cáceres, J. J., Cabrera, J., Uribe, L., Ferrer-Moure, C., & Jiménez, A. (2021). Mortality prediction of patients with spontaneous intracerebral hemorrhage by serum soluble Fas ligand concentrations. Expert review of molecular diagnostics, 1-6. https://doi.org/10.1080/14737159.2022.2017775
Lorente, Leonardo, et al. "Mortality prediction of patients with spontaneous intracerebral hemorrhage by serum soluble Fas ligand concentrations." Expert review of molecular diagnostics vol. (2021): 1-6. doi: https://doi.org/10.1080/14737159.2022.2017775
Lorente L, Martín MM, Pérez-Cejas A, González-Rivero AF, Ramos-Gómez L, Solé-Violán J, Cáceres JJ, Cabrera J, Uribe L, Ferrer-Moure C, Jiménez A. Mortality prediction of patients with spontaneous intracerebral hemorrhage by serum soluble Fas ligand concentrations. Expert Rev Mol Diagn. 2021 Dec 22;1-6. doi: 10.1080/14737159.2022.2017775. Epub 2021 Dec 22. PMID: 34894981.
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Expert Rev Mol Diagn. 2021 Dec 22;1-6. doi: 10.1080/14737159.2022.2017775. Epub 2021 Dec 22.

Mortality prediction of patients with spontaneous intracerebral hemorrhage by serum soluble Fas ligand concentrations.

Expert review of molecular diagnostics

Leonardo Lorente, María M Martín, Antonia Pérez-Cejas, Agustín F González-Rivero, Luis Ramos-Gómez, Jordi Solé-Violán, Juan J Cáceres, Judith Cabrera, Luis Uribe, Carmen Ferrer-Moure, Alejandro Jiménez

Affiliations

  1. Intensive Care Unit, Hospital Universitario de Canarias, La Laguna Santa Cruz de Tenerife, Spain.
  2. Intensive Care Unit, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
  3. Laboratory Department, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.
  4. Intensive Care Unit, Hospital General La Palma, Spain.
  5. Intensive Care Unit, Hospital Universitario Dr. Negrín. CIBERES, Las Palmas de Gran Canaria, Spain.
  6. Intensive Care Unit, Hospital Insular, Las Palmas de Gran Canaria, Spain.
  7. Laboratory Department, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain.
  8. Research Unit, Hospital Universitario de Canarias, La Laguna. Santa Cruz de Tenerife, Spain.

PMID: 34894981 DOI: 10.1080/14737159.2022.2017775

Abstract

BACKGROUND: A study of patients with spontaneous intracerebral hemorrhage (SIH) found a higher content of Fas ligand in the perihematomic brain area compared to healthy brain areas. The objective of this study was to analyze whether blood soluble Fas ligand (sFasL) concentrations could be used to estimate the prognosis of SIH patients.

METHODS: Observational and prospective study performed in five Spanish Intensive Care Units. Patients with

RESULTS: Surviving SIH patients (

CONCLUSIONS: The capability of serum sFasL to predict SIH patient mortality is the main novel finding of our study.

ABBREVIATIONS: APACHE II: Acute Physiology and Chronic Health Evaluation; aPTT: activated partial thromboplastin time; FIO

Keywords: Spontaneous intracerebral hemorrhage; apoptosis; mortality; patients; sFasL

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