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Song Y, Yang X, Yu B. Repurposing antidepressants for anticancer drug discovery. Drug Discov Today. 2021;doi: 10.1016/j.drudis.2021.10.019.
Song, Y., Yang, X., & Yu, B. (2021). Repurposing antidepressants for anticancer drug discovery. Drug discovery today, . https://doi.org/10.1016/j.drudis.2021.10.019
Song, Yihui, et al. "Repurposing antidepressants for anticancer drug discovery." Drug discovery today vol. (2021). doi: https://doi.org/10.1016/j.drudis.2021.10.019
Song Y, Yang X, Yu B. Repurposing antidepressants for anticancer drug discovery. Drug Discov Today. 2021 Oct 30; doi: 10.1016/j.drudis.2021.10.019. Epub 2021 Oct 30. PMID: 34728374.
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Drug Discov Today. 2021 Oct 30; doi: 10.1016/j.drudis.2021.10.019. Epub 2021 Oct 30.

Repurposing antidepressants for anticancer drug discovery.

Drug discovery today

Yihui Song, Xiaoke Yang, Bin Yu

Affiliations

  1. School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou 450001, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100000, China.
  2. School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou 450001, China.
  3. School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou 450001, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100000, China. Electronic address: [email protected].

PMID: 34728374 DOI: 10.1016/j.drudis.2021.10.019

Abstract

Drug repurposing is an attractive strategy for identifying new indications for existing drugs. Three approved antidepressants have advanced into clinical trials for cancer therapy. In particular, further medicinal chemistry efforts with tranylcypromine (TCP) have led to the discovery of several TCP-based histone lysine specific demethylase 1 (LSD1) inhibitors that display therapeutic promise for treating cancer in the clinic. Thus repurposing antidepressants could be a promising strategy for cancer treatment. In this review, we illustrate the anticancer mechanisms of action of antidepressants and also discuss the challenges and future directions of repurposing antidepressants for anticancer drug discovery, to provide an overview of approved antidepressant cancer therapies.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Anticancer drug discovery; Antidepressants; Drug repurposing

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