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Wei S, Hao JW, Qiao WL, et al. Suppression of ASIC activity by the activation of A1 adenosine receptors in rat primary sensory neurons. Neuropharmacology. 2021;205:108924doi: 10.1016/j.neuropharm.2021.108924.
Wei, S., Hao, J. W., Qiao, W. L., Li, Q., Liu, T. T., Qiu, C. Y., & Hu, W. P. (2021). Suppression of ASIC activity by the activation of A1 adenosine receptors in rat primary sensory neurons. Neuropharmacology, 205108924. https://doi.org/10.1016/j.neuropharm.2021.108924
Wei, Shuang, et al. "Suppression of ASIC activity by the activation of A1 adenosine receptors in rat primary sensory neurons." Neuropharmacology vol. 205 (2021): 108924. doi: https://doi.org/10.1016/j.neuropharm.2021.108924
Wei S, Hao JW, Qiao WL, Li Q, Liu TT, Qiu CY, Hu WP. Suppression of ASIC activity by the activation of A1 adenosine receptors in rat primary sensory neurons. Neuropharmacology. 2021 Dec 15;205:108924. doi: 10.1016/j.neuropharm.2021.108924. Epub 2021 Dec 15. PMID: 34919904.
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Neuropharmacology. 2021 Dec 15;205:108924. doi: 10.1016/j.neuropharm.2021.108924. Epub 2021 Dec 15.

Suppression of ASIC activity by the activation of A1 adenosine receptors in rat primary sensory neurons.

Neuropharmacology

Shuang Wei, Jia-Wei Hao, Wen-Long Qiao, Qing Li, Ting-Ting Liu, Chun-Yu Qiu, Wang-Ping Hu

Affiliations

  1. School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, 88 Xianning Road, Xianning, 437100, Hubei, PR China.
  2. School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, 88 Xianning Road, Xianning, 437100, Hubei, PR China; Hubei College of Chinese Medicine, 87 Xueyuan Road, Jingzhou, 434020, Hubei, PR China. Electronic address: [email protected].

PMID: 34919904 DOI: 10.1016/j.neuropharm.2021.108924

Abstract

Peripheral A1 adenosine receptor signaling has been shown to have analgesic effects in a variety of pain conditions. However, it is not yet fully elucidated for the precise molecular mechanisms. Acid sensing ion channels (ASICs) are expressed predominantly in nociceptive sensory neurons responding to protons. Given that both A1 adenosine receptors and ASICs are present in dorsal root ganglia (DRG) neurons, we therefore investigated whether there was a cross-talk between the two types of receptors. Herein, electrophysiological recordings showed that the A1 adenosine receptor agonist N

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: A1 adenosine receptor; Acid-sensing ion channel; Dorsal root ganglion neuron; Electrophysiology; Nociceptive behavior

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