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Montesino B, Steenackers A, Lozano JM, et al. Identification of α1,2-Fucosylated Signaling and adhesion molecules in head and neck squamous cell carcinoma. Glycobiology. 2021;doi: 10.1093/glycob/cwab131.
Montesino, B., Steenackers, A., Lozano, J. M., Young, G. D., Hu, N., Sackstein, R., & Chandler, K. B. (2021). Identification of α1,2-Fucosylated Signaling and adhesion molecules in head and neck squamous cell carcinoma. Glycobiology, . https://doi.org/10.1093/glycob/cwab131
Montesino, Brittany, et al. "Identification of α1,2-Fucosylated Signaling and adhesion molecules in head and neck squamous cell carcinoma." Glycobiology vol. (2021). doi: https://doi.org/10.1093/glycob/cwab131
Montesino B, Steenackers A, Lozano JM, Young GD, Hu N, Sackstein R, Chandler KB. Identification of α1,2-Fucosylated Signaling and adhesion molecules in head and neck squamous cell carcinoma. Glycobiology. 2021 Dec 22; doi: 10.1093/glycob/cwab131. Epub 2021 Dec 22. PMID: 34939118.
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Glycobiology. 2021 Dec 22; doi: 10.1093/glycob/cwab131. Epub 2021 Dec 22.

Identification of α1,2-Fucosylated Signaling and adhesion molecules in head and neck squamous cell carcinoma.

Glycobiology

Brittany Montesino, Agata Steenackers, Juan M Lozano, Geoffrey D Young, Nan Hu, Robert Sackstein, Kevin Brown Chandler

Affiliations

  1. Translational Glycobiology Institute, Department of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199 USA.
  2. Division of Medical and Population Health Science Education and Research, Florida International University Herbert Wertheim College of Medicine, Miami, FL, USA.
  3. Miami Cancer Institute Miami, FL, 33176 USA.
  4. Department of Surgery, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199 USA.
  5. Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199 USA.
  6. Biomolecular Sciences Institute, Florida International University, Miami, FL 33199, USA.

PMID: 34939118 DOI: 10.1093/glycob/cwab131

Abstract

Head and neck cancer is the seventh most common cancer in the world, and most cases manifest as head and neck squamous cell carcinoma. Despite the prominent role of fucosylated carbohydrate antigens in tumor cell adhesion and metastasis, little is known about the functional role of fucose-modified glycoproteins in head and neck cancer pathobiology. Inactivating polymorphisms of the fut2 gene, encoding for the α1,2-fucosyltransferase FUT2, are associated with an increased incidence of head and neck cancer among tobacco users. Moreover, the presence of the α1,2-fucosylated Lewis Y epitope, with both α1,2- and α1,3-linked fucose, has been observed in head and neck cancer tumors while invasive regions lose expression, suggesting a potential role for α1,2-fucosylation in the regulation of aggressive tumor cell characteristics. Here, we report an association between fut2 expression and head and neck cancer survival, document differential surface expression of α1,2-fucosylated epitopes in a panel of normal, dysplastic, and head and neck cancer cell lines, identify a set of potentially α1,2-fucosylated signaling and adhesion molecules including the epidermal growth factor receptor EGFR, CD44, and integrins via tandem mass spectrometry, and finally, present evidence that EGFR is among the α1,2-fucosylated and LeY-displaying proteins in head and neck cancer. This knowledge will serve as the foundation for future studies to interrogate the role of LeY-modified and α1,2-fucosylated glycoproteins in head and neck cancer pathogenesis. Data are available via ProteomeXchange with identifier PXD029420.

© The Author(s) 2021. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: [email protected].

Keywords: 2-fucosylation; EGFR; FUT2; epidermal growth factor receptor; head and neck squamous cell carcinoma; α1

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