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Fonseca FJ, Ferreira L, Rouxinol-Dias AL, et al. Effects of dexmedetomidine in non-operating room anesthesia in adults: a systematic review with meta-analysis. Braz J Anesthesiol. 2021;doi: 10.1016/j.bjane.2021.12.002.
Fonseca, F. J., Ferreira, L., Rouxinol-Dias, A. L., & Mourão, J. (2021). Effects of dexmedetomidine in non-operating room anesthesia in adults: a systematic review with meta-analysis. Brazilian journal of anesthesiology (Elsevier), . https://doi.org/10.1016/j.bjane.2021.12.002
Fonseca, Francisca Jerónimo, et al. "Effects of dexmedetomidine in non-operating room anesthesia in adults: a systematic review with meta-analysis." Brazilian journal of anesthesiology (Elsevier) vol. (2021). doi: https://doi.org/10.1016/j.bjane.2021.12.002
Fonseca FJ, Ferreira L, Rouxinol-Dias AL, Mourão J. Effects of dexmedetomidine in non-operating room anesthesia in adults: a systematic review with meta-analysis. Braz J Anesthesiol. 2021 Dec 18; doi: 10.1016/j.bjane.2021.12.002. Epub 2021 Dec 18. PMID: 34933035.
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Braz J Anesthesiol. 2021 Dec 18; doi: 10.1016/j.bjane.2021.12.002. Epub 2021 Dec 18.

Effects of dexmedetomidine in non-operating room anesthesia in adults: a systematic review with meta-analysis.

Brazilian journal of anesthesiology (Elsevier)

Francisca Jerónimo Fonseca, Leonardo Ferreira, Ana Lídia Rouxinol-Dias, Joana Mourão

Affiliations

  1. Faculty of Medicine of the University of Porto, Porto, Portugal.
  2. São João University Hospital Center, Department of Anesthesiology, Porto, Portugal. Electronic address: [email protected].
  3. Faculty of Medicine of the University of Porto, Porto, Portugal; São João University Hospital Center, Department of Anesthesiology, Porto, Portugal; Faculty of Medicine of the University of Porto, Department of Community Medicine, Information and Decision in Health, MEDCIDS, Porto, Portugal.
  4. Faculty of Medicine of the University of Porto, Porto, Portugal; São João University Hospital Center, Department of Anesthesiology, Porto, Portugal; Faculty of Medicine of the University of Porto, Center for Health Technology and Services Research, CINTESIS, Porto, Portugal.

PMID: 34933035 DOI: 10.1016/j.bjane.2021.12.002

Abstract

BACKGROUND: DEX is an α2-adrenergic receptor agonist used for its sedative, analgesic, and anxiolytic effects. NORA is a modality of anesthesia that can be done under general anesthesia or procedural sedation or/and analgesia. In this particular setting, a level 2 sedation, such as the one provided by DEX, is beneficial. We aimed to study the effects and safety of Dexmedetomidine (DEX) in the different Non-Operating Room Anesthesia (NORA) settings in the adult population.

METHODS: A systematic review with meta-analysis of randomized controlled trials was conducted. Interventions using DEX only or DEX associated with other sedative agents, in adults (18 years old or older), were included. Procedures outside the NORA setting and/or without a control group without DEX were excluded. MEDLINE, ClinicalTrials.gov, Scopus, LILACS, and SciELO were searched. The primary outcome was time until full recovery. Secondary outcomes included hemodynamic and respiratory complications and other adverse events, among others.

RESULTS: A total of 97 studies were included with a total of 6,706 participants. The meta-analysis demonstrated that DEX had a higher time until full recovery (95% CI = [0.34, 3.13] minutes, a higher incidence of hypotension (OR = 1.95 [1.25, 3.05], p = 0.003, I

CONCLUSION: DEX in NORA procedures in adults was associated with a lower incidence of amnesia and respiratory effects but had a long time to recovery and more hemodynamic complications.

Copyright © 2021. Published by Elsevier Editora Ltda.

Keywords: Anesthesiology; Conscious sedation; Dexmedetomidine; Hypnotics and sedatives; Patient safety

Conflict of interest statement

Conflicts of interest The authors declare no conflicts of interest.

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