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Kazakov AS, Sokolov AS, Permyakova ME, et al. Specific cytokines of interleukin-6 family interact with S100 proteins. Cell Calcium. 2021;101:102520doi: 10.1016/j.ceca.2021.102520.
Kazakov, A. S., Sokolov, A. S., Permyakova, M. E., Litus, E. A., Uversky, V. N., Permyakov, E. A., & Permyakov, S. E. (2021). Specific cytokines of interleukin-6 family interact with S100 proteins. Cell calcium, 101102520. https://doi.org/10.1016/j.ceca.2021.102520
Kazakov, Alexey S, et al. "Specific cytokines of interleukin-6 family interact with S100 proteins." Cell calcium vol. 101 (2021): 102520. doi: https://doi.org/10.1016/j.ceca.2021.102520
Kazakov AS, Sokolov AS, Permyakova ME, Litus EA, Uversky VN, Permyakov EA, Permyakov SE. Specific cytokines of interleukin-6 family interact with S100 proteins. Cell Calcium. 2021 Dec 14;101:102520. doi: 10.1016/j.ceca.2021.102520. Epub 2021 Dec 14. PMID: 34933172.
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Cell Calcium. 2021 Dec 14;101:102520. doi: 10.1016/j.ceca.2021.102520. Epub 2021 Dec 14.

Specific cytokines of interleukin-6 family interact with S100 proteins.

Cell calcium

Alexey S Kazakov, Andrey S Sokolov, Maria E Permyakova, Ekaterina A Litus, Vladimir N Uversky, Eugene A Permyakov, Sergei E Permyakov

Affiliations

  1. Institute for Biological Instrumentation, Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, Institutskaya str., 7, Pushchino, Moscow region 142290 Russia.
  2. Department of Molecular Medicine and Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL MDC07, USA. Electronic address: [email protected].
  3. Institute for Biological Instrumentation, Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, Institutskaya str., 7, Pushchino, Moscow region 142290 Russia. Electronic address: [email protected].

PMID: 34933172 DOI: 10.1016/j.ceca.2021.102520

Abstract

Cytokines of interleukin-6 (IL-6) family are important signaling proteins involved in various physiological and pathological processes. Earlier, we described interactions between IL-11 and S100P/B proteins from the family of S100 proteins engaged in the pathogenesis of numerous diseases. We probed here interactions between seven IL-6 family cytokines (IL-6, IL-11, OSM, LIF, CNTF, CT-1, and CLCF1) and fourteen S100 proteins (S100A1/A4/A6/A7/A8/A9/A10/A11/A12/A13/A14/A15/B/P). Surface plasmon resonance spectroscopy revealed formation of calcium-dependent complexes between IL-11, OSM, CNTF, CT-1, and CLCF1 and distinct subsets of S100A1/A6/B/P proteins with equilibrium dissociation constants of 19 nM - 12 µM. The existence of a network of interactions between Ca

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: CLCF1; CNTF; COPD; CT-1; IBD; IL-11; IL-6; JAK; Janus kinase; LIF; OSM; RU; SARS-CoV-2; SPR; STAT; cardiotrophin-1; cardiotrophin-like cytokine factor 1; chronic obstructive pulmonary disease; ciliary neurotrophic factor; gp130; inflammatory bowel disease; interleukin-11; interleukin-6; leukemia inhibitory factor; membrane glycoprotein 130; oncostatin-M; resonance unit; severe acute respiratory syndrome coronavirus-2; signal transducer and activator of transcription; surface plasmon resonance

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