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Nussenblatt V, Roder AE, Das S, et al. Year-long COVID-19 infection reveals within-host evolution of SARS-CoV-2 in a patient with B cell depletion. J Infect Dis. 2021;doi: 10.1093/infdis/jiab622.
Nussenblatt, V., Roder, A. E., Das, S., de Wit, E., Youn, J. H., Banakis, S., Mushegian, A., Mederos, C., Wang, W., Chung, M., Pérez-Pérez, L., Palmore, T., Brudno, J. N., Kochenderfer, J. N., & Ghedin, E. (2021). Year-long COVID-19 infection reveals within-host evolution of SARS-CoV-2 in a patient with B cell depletion. The Journal of infectious diseases, . https://doi.org/10.1093/infdis/jiab622
Nussenblatt, Veronique, et al. "Year-long COVID-19 infection reveals within-host evolution of SARS-CoV-2 in a patient with B cell depletion." The Journal of infectious diseases vol. (2021). doi: https://doi.org/10.1093/infdis/jiab622
Nussenblatt V, Roder AE, Das S, de Wit E, Youn JH, Banakis S, Mushegian A, Mederos C, Wang W, Chung M, Pérez-Pérez L, Palmore T, Brudno JN, Kochenderfer JN, Ghedin E. Year-long COVID-19 infection reveals within-host evolution of SARS-CoV-2 in a patient with B cell depletion. J Infect Dis. 2021 Dec 23; doi: 10.1093/infdis/jiab622. Epub 2021 Dec 23. PMID: 34940844.
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J Infect Dis. 2021 Dec 23; doi: 10.1093/infdis/jiab622. Epub 2021 Dec 23.

Year-long COVID-19 infection reveals within-host evolution of SARS-CoV-2 in a patient with B cell depletion.

The Journal of infectious diseases

Veronique Nussenblatt, Allison E Roder, Sanchita Das, Emmie de Wit, Jung-Ho Youn, Stephanie Banakis, Alexandra Mushegian, Christopher Mederos, Wei Wang, Matthew Chung, Lizzette Pérez-Pérez, Tara Palmore, Jennifer N Brudno, James N Kochenderfer, Elodie Ghedin

Affiliations

  1. Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD 20854, USA.
  2. Systems Genomics Section, Laboratory of Parasitic Diseases, DIR, NIAID, NIH, Bethesda, MD 20894, USA.
  3. Department of Laboratory Medicine, NIH, Bethesda, MD 20894, USA.
  4. Laboratory of Virology, DIR, NIAID, NIH, Hamilton, MT, USA.
  5. Clinical Center, NIH, Bethesda, MD 20854, USA.
  6. Surgery Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20894, USA.

PMID: 34940844 DOI: 10.1093/infdis/jiab622

Abstract

B-cell depleting therapies may lead to prolonged disease and viral shedding in individuals infected with SARS-CoV-2 and this viral persistence raises concern for viral evolution. We report on the sequencing of early and late samples from a 335-day infection in an immunocompromised patient. The virus accumulated a unique deletion in the amino-terminal domain of the spike protein, and complete deletion of ORF7b and ORF8, the first report of its kind in an immunocompromised patient. Overall, the unique viral mutations found in this study highlight the importance of analyzing viral evolution in protracted SARS-CoV-2 infection, especially in immunosuppressed hosts.

Published by Oxford University Press for the Infectious Diseases Society of America 2021. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Keywords: COVID-19; SARS-CoV-2; immunocompromised; prolonged infection; viral evolution

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