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Muntean BS, Marwari S, Li X, et al. Members of the KCTD family are major regulators of cAMP signaling. Proc Natl Acad Sci U S A. 2022;119(1)doi: 10.1073/pnas.2119237119.
Muntean, B. S., Marwari, S., Li, X., Sloan, D. C., Young, B. D., Wohlschlegel, J. A., & Martemyanov, K. A. (2022). Members of the KCTD family are major regulators of cAMP signaling. Proceedings of the National Academy of Sciences of the United States of America, 119(1), . https://doi.org/10.1073/pnas.2119237119
Muntean, Brian S, et al. "Members of the KCTD family are major regulators of cAMP signaling." Proceedings of the National Academy of Sciences of the United States of America vol. 119,1 (2022). doi: https://doi.org/10.1073/pnas.2119237119
Muntean BS, Marwari S, Li X, Sloan DC, Young BD, Wohlschlegel JA, Martemyanov KA. Members of the KCTD family are major regulators of cAMP signaling. Proc Natl Acad Sci U S A. 2022 Jan 04;119(1). doi: 10.1073/pnas.2119237119. PMID: 34934014.
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Proc Natl Acad Sci U S A. 2022 Jan 04;119(1). doi: 10.1073/pnas.2119237119.

Members of the KCTD family are major regulators of cAMP signaling.

Proceedings of the National Academy of Sciences of the United States of America

Brian S Muntean, Subhi Marwari, Xiaona Li, Douglas C Sloan, Brian D Young, James A Wohlschlegel, Kirill A Martemyanov

Affiliations

  1. Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458; [email protected] [email protected].
  2. Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912.
  3. Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458.
  4. Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095.

PMID: 34934014 DOI: 10.1073/pnas.2119237119

Abstract

Cyclic adenosine monophosphate (cAMP) is a pivotal second messenger with an essential role in neuronal function. cAMP synthesis by adenylyl cyclases (AC) is controlled by G protein-coupled receptor (GPCR) signaling systems. However, the network of molecular players involved in the process is incompletely defined. Here, we used CRISPR/Cas9-based screening to identify that members of the potassium channel tetradimerization domain (KCTD) family are major regulators of cAMP signaling. Focusing on striatal neurons, we show that the dominant isoform KCTD5 exerts its effects through an unusual mechanism that modulates the influx of Zn

Copyright © 2021 the Author(s). Published by PNAS.

Keywords: GPCR; cAMP; neuron; striatum; zinc

Conflict of interest statement

The authors declare no competing interest.

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