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Roukens AHE, Pothast CR, König M, et al. Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8. Nat Immunol. 2021;23(1):23-32doi: 10.1038/s41590-021-01095-w.
Roukens, A. H. E., Pothast, C. R., König, M., Huisman, W., Dalebout, T., Tak, T., Azimi, S., Kruize, Y., Hagedoorn, R. S., Zlei, M., Staal, F. J. T., de Bie, F. J., van Dongen, J. J. M., Arbous, S. M., Zhang, J. L. H., Verheij, M., Prins, C., van der Does, A. M., Hiemstra, P. S., de Vries, J. J. C., Janse, J. J., Roestenberg, M., Myeni, S. K., Kikkert, M., Yazdanbakhsh, M., Heemskerk, M. H. M., Smits, H. H., Jochems, S. P. (2022). Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8. Nature immunology, 23(1), 23-32. https://doi.org/10.1038/s41590-021-01095-w
Roukens, Anna H E, et al. "Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8." Nature immunology vol. 23,1 (2022): 23-32. doi: https://doi.org/10.1038/s41590-021-01095-w
Roukens AHE, Pothast CR, König M, Huisman W, Dalebout T, Tak T, Azimi S, Kruize Y, Hagedoorn RS, Zlei M, Staal FJT, de Bie FJ, van Dongen JJM, Arbous SM, Zhang JLH, Verheij M, Prins C, van der Does AM, Hiemstra PS, de Vries JJC, Janse JJ, Roestenberg M, Myeni SK, Kikkert M, Yazdanbakhsh M, Heemskerk MHM, Smits HH, Jochems SP. Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8. Nat Immunol. 2022 Jan;23(1):23-32. doi: 10.1038/s41590-021-01095-w. Epub 2021 Dec 22. PMID: 34937933.
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Nat Immunol. 2022 Jan;23(1):23-32. doi: 10.1038/s41590-021-01095-w. Epub 2021 Dec 22.

Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8.

Nature immunology

Anna H E Roukens, Cilia R Pothast, Marion König, Wesley Huisman, Tim Dalebout, Tamar Tak, Shohreh Azimi, Yvonne Kruize, Renate S Hagedoorn, Mihaela Zlei, Frank J T Staal, Fenna J de Bie, Jacques J M van Dongen, Sesmu M Arbous, Jaimie L H Zhang, Maaike Verheij, Corine Prins, Anne M van der Does, Pieter S Hiemstra, Jutte J C de Vries, Jacqueline J Janse, Meta Roestenberg, Sebenzile K Myeni, Marjolein Kikkert, Maria Yazdanbakhsh, Mirjam H M Heemskerk, Hermelijn H Smits, Simon P Jochems,

Affiliations

  1. Department of Infectious Diseases, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
  2. Department of Hematology, Leiden University Medical Center, Leiden, the Netherlands.
  3. Department of Parasitology, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
  4. Department of Medical Microbiology, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
  5. Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
  6. Department of Intensive Care, Leiden University Medical Center, Leiden, the Netherlands.
  7. Department of Pulmonology, Leiden University Medical Center, Leiden, the Netherlands.
  8. Department of Parasitology, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands. [email protected].

PMID: 34937933 DOI: 10.1038/s41590-021-01095-w

Abstract

Systemic immune cell dynamics during coronavirus disease 2019 (COVID-19) are extensively documented, but these are less well studied in the (upper) respiratory tract, where severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates

© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.

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