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J Cardiovasc Dev Dis. 2021 Dec 14;8(12). doi: 10.3390/jcdd8120187.

Enhanced Liver Fibrosis Score as a Biomarker for Vascular Damage Assessment in Patients with Takayasu Arteritis-A Pilot Study.

Journal of cardiovascular development and disease

Maja Stojanovic, Sanvila Raskovic, Vladimir Milivojevic, Rada Miskovic, Ivan Soldatovic, Sanja Stankovic, Ivan Rankovic, Marija Stankovic Stanojevic, Sanja Dragasevic, Miodrag Krstic, Andreas P Diamantopoulos

Affiliations

  1. Clinic for Allergy and Immunology, University Clinical Center of Serbia, Koste Todorovica 2, 11000 Belgrade, Serbia.
  2. Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  3. Clinic of Gastroenterohepatology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
  4. Institute of Medical Statistics and Informatic, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  5. Center for Medical Biochemistry, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
  6. Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
  7. Department of Pathophysiology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  8. Department of Rheumatology, Akershus University Hospital, 1478 Lørenskog, Norway.

PMID: 34940542 PMCID: PMC8709028 DOI: 10.3390/jcdd8120187

Abstract

Takayasu Arteritis (TA) is characterized by granulomatous panarteritis, vessel wall fibrosis, and irreversible vascular impairment. The aim of this study is to explore the usefulness of the Enhanced Liver Fibrosis score (ELF), procollagen-III aminoterminal propeptide (PIIINP), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), and hyaluronic acid (HA) in assessing vascular damage in TA patients. ELF, PIIINP, TIMP-1, and HA were measured in 24 TA patients, and the results were correlated with the clinical damage indexes (VDI and TADS), an imaging damage score (CARDS), and disease activity scores (NIH and ITAS2010). A mean ELF score 8.42 (±1.12) and values higher than 7.7 (cut-off for liver fibrosis) in 21/24 (87.5%) of patients were detected. The VDI and TADS correlated significantly to ELF (

Keywords: ELF; Takayasu Arteritis; biomarkers; vascular damage; vasculitis

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