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Tüngler A, Van der Auwera S, Wittfeld K, et al. Body mass index but not genetic risk is longitudinally associated with altered structural brain parameters. Sci Rep. 2021;11(1):24246doi: 10.1038/s41598-021-03343-3.
Tüngler, A., Van der Auwera, S., Wittfeld, K., Frenzel, S., Terock, J., Röder, N., Homuth, G., Völzke, H., Bülow, R., Grabe, H. J., & Janowitz, D. (2021). Body mass index but not genetic risk is longitudinally associated with altered structural brain parameters. Scientific reports, 11(1), 24246. https://doi.org/10.1038/s41598-021-03343-3
Tüngler, Anne, et al. "Body mass index but not genetic risk is longitudinally associated with altered structural brain parameters." Scientific reports vol. 11,1 (2021): 24246. doi: https://doi.org/10.1038/s41598-021-03343-3
Tüngler A, Van der Auwera S, Wittfeld K, Frenzel S, Terock J, Röder N, Homuth G, Völzke H, Bülow R, Grabe HJ, Janowitz D. Body mass index but not genetic risk is longitudinally associated with altered structural brain parameters. Sci Rep. 2021 Dec 20;11(1):24246. doi: 10.1038/s41598-021-03343-3. PMID: 34930940; PMCID: PMC8688483.
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Sci Rep. 2021 Dec 20;11(1):24246. doi: 10.1038/s41598-021-03343-3.

Body mass index but not genetic risk is longitudinally associated with altered structural brain parameters.

Scientific reports

Anne Tüngler, Sandra Van der Auwera, Katharina Wittfeld, Stefan Frenzel, Jan Terock, Nele Röder, Georg Homuth, Henry Völzke, Robin Bülow, Hans Jörgen Grabe, Deborah Janowitz

Affiliations

  1. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Ellernholzstraße 1-2, 17475, Greifswald, Germany.
  2. German Center for Neurodegenerative Diseases DZNE, Site Rostock/Greifswald, Ellernholzstraße 1-2, 17475, Greifswald, Germany.
  3. Department of Psychiatry and Psychotherapy, HELIOS Hanseklinikum Stralsund, Rostocker Chaussee 70, 18437, Stralsund, Germany.
  4. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Felix-Hausdorff-Str. 8, 17475, Greifswald, Germany.
  5. Institute for Community Medicine, University Medicine Greifswald, Walther-Rathenau-Str. 48, 17487, Greifswald, Germany.
  6. Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Ferdinand-Sauerbruch-Str., 17475, Greifswald, Germany.
  7. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Ellernholzstraße 1-2, 17475, Greifswald, Germany. [email protected].
  8. Department of Psychiatry and Psychotherapy, HELIOS Hanseklinikum Stralsund, Rostocker Chaussee 70, 18437, Stralsund, Germany. [email protected].

PMID: 34930940 PMCID: PMC8688483 DOI: 10.1038/s41598-021-03343-3

Abstract

Evidence from previous studies suggests that elevated body mass index (BMI) and genetic risk for obesity is associated with reduced brain volume, particularly in areas of reward-related cognition, e.g. the medial prefrontal cortex (AC-MPFC), the orbitofrontal cortex (OFC), the striatum and the thalamus. However, only few studies examined the interplay between these factors in a joint approach. Moreover, previous findings are based on cross-sectional data. We investigated the longitudinal relationship between increased BMI, brain structural magnetic resonance imaging (MRI) parameters and genetic risk scores in a cohort of n = 502 community-dwelling participants from the Study of Health in Pomerania (SHIP) with a mean follow-up-time of 4.9 years. We found that (1) increased BMI values at baseline were associated with decreased brain parameters at follow-up. These effects were particularly pronounced for the OFC and AC-MPFC. (2) The genetic predisposition for BMI had no effect on brain parameters at baseline or follow-up. (3) The interaction between the genetic score for BMI and brain parameters had no effect on BMI at baseline. Finding a significant impact of overweight, but not genetic predisposition for obesity on altered brain structure suggests that metabolic mechanisms may underlie the relationship between obesity and altered brain structure.

© 2021. The Author(s).

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