Display options
Cite
Sanz MA, Barragán E. History of Acute Promyelocytic Leukemia. Clin Hematol Int. 2021;3(4):142-152doi: 10.2991/chi.k.210703.001.
Sanz, M. A., & Barragán, E. (2021). History of Acute Promyelocytic Leukemia. Clinical hematology international, 3(4), 142-152. https://doi.org/10.2991/chi.k.210703.001
Sanz, Miguel A, and Barragán, Eva. "History of Acute Promyelocytic Leukemia." Clinical hematology international vol. 3,4 (2021): 142-152. doi: https://doi.org/10.2991/chi.k.210703.001
Sanz MA, Barragán E. History of Acute Promyelocytic Leukemia. Clin Hematol Int. 2021 Jul 19;3(4):142-152. doi: 10.2991/chi.k.210703.001. eCollection 2021 Dec. PMID: 34938986; PMCID: PMC8690702.
Copy Download .nbib Format: NLM
Share it on

Clin Hematol Int. 2021 Jul 19;3(4):142-152. doi: 10.2991/chi.k.210703.001. eCollection 2021 Dec.

History of Acute Promyelocytic Leukemia.

Clinical hematology international

Miguel A Sanz, Eva Barragán

Affiliations

  1. Department of Hematology, Instituto de Investigación Sanitaria La Fe, Valencia, Spain.
  2. Clinical Laboratory, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
  3. Centro de Investigación Biomédica en Red de Cáncer, Carlos III Institute, Madrid, Spain.

PMID: 34938986 PMCID: PMC8690702 DOI: 10.2991/chi.k.210703.001

Abstract

In this article, we discuss the history of acute promyelocytic leukemia (APL) from the pre-therapeutic era, which began after its recognition by Hillestad in 1947 as a nosological entity, to the present day. It is a paradigmatic history that has transformed the "most malignant leukemia form" into the most curable one. The identification of a balanced reciprocal translocation between chromosomes 15 and 17, resulting in fusion between the promyelocytic leukemia gene and the retinoic acid receptor alpha, has been crucial in understanding the mechanisms of leukemogenesis, and responsible for the peculiar response to targeted therapy with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). We review the milestones that marked successive therapeutic advances, beginning with the introduction of the first successful chemotherapy in the early 1970s, followed by a subsequent incorporation of ATRA and ATO in the late 1980s and early 1990s which have revolutionized the treatment of this disease. Over the past two decades, treatment optimization has relied on the combination of ATRA, ATO, and chemotherapy according to risk-adapted approaches, which together with improvements in supportive therapy have paved the way for cure for most patients with APL.

© 2021 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.

Keywords: Acute promeloctic leukemia; all-trans retinoic acid; arsenic trioxide

Conflict of interest statement

The authors declare they have no conflicts of interest.

References

  1. Leuk Lymphoma. 1991;4(4):239-48 - PubMed
  2. Blood. 2002 Nov 1;100(9):3141-6 - PubMed
  3. Blood. 1999 Nov 1;94(9):3015-21 - PubMed
  4. Cancer. 2018 Jun 1;124(11):2316-2326 - PubMed
  5. Nouv Rev Fr Hematol. 1984;26(6):371-8 - PubMed
  6. Br J Haematol. 1976 Aug;33(4):451-8 - PubMed
  7. Lancet. 1977 Mar 5;1(8010):549-50 - PubMed
  8. Blood. 2019 Aug 15;134(7):597-605 - PubMed
  9. Science. 1990 Sep 28;249(4976):1577-80 - PubMed
  10. Hum Mol Genet. 2001 Apr;10(7):769-75 - PubMed
  11. Blood. 1986 Feb;67(2):559-61 - PubMed
  12. Blood. 1999 Nov 15;94(10):3315-24 - PubMed
  13. Blood. 2017 Mar 9;129(10):1275-1283 - PubMed
  14. Lancet. 1992 Dec 12;340(8833):1437-8 - PubMed
  15. Br J Haematol. 1984 Jul;57(3):365-71 - PubMed
  16. Blood. 1993 Dec 1;82(11):3241-9 - PubMed
  17. N Engl J Med. 1998 Nov 5;339(19):1341-8 - PubMed
  18. N Engl J Med. 2013 Jul 11;369(2):111-21 - PubMed
  19. Blood. 1999 Jun 15;93(12):4131-43 - PubMed
  20. Blood. 1992 Jul 15;80(2):492-7 - PubMed
  21. Blood. 2019 Apr 11;133(15):1630-1643 - PubMed
  22. J Clin Oncol. 1997 Feb;15(2):483-90 - PubMed
  23. Lancet Oncol. 2018 Jul;19(7):871-879 - PubMed
  24. Blood. 2008 Oct 15;112(8):3130-4 - PubMed
  25. J Clin Oncol. 2009 Aug 1;27(22):3650-8 - PubMed
  26. Acta Med Scand. 1957 Nov 29;159(3):189-94 - PubMed
  27. Lancet. 1978 Oct 7;2(8093):797 - PubMed
  28. Blood. 1991 Sep 15;78(6):1413-9 - PubMed
  29. Blood. 1997 Dec 15;90(12):4876-85 - PubMed
  30. Blood. 1997 May 1;89(9):3354-60 - PubMed
  31. Br J Haematol. 2000 Jan;108(1):90-2 - PubMed
  32. Cell. 2002 Jan 25;108(2):165-70 - PubMed
  33. Am J Med. 1986 May;80(5):789-97 - PubMed
  34. Leukemia. 1994;8 Suppl 2:S38-41 - PubMed
  35. Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5328-35 - PubMed
  36. Blood. 1992 Nov 1;80(9):2176-81 - PubMed
  37. Leukemia. 2000 Aug;14(8):1362-70 - PubMed
  38. Blood. 1997 Aug 1;90(3):1014-21 - PubMed
  39. Blood. 2000 Aug 15;96(4):1297-308 - PubMed
  40. Blood. 1992 Jun 15;79(12):3110-5 - PubMed
  41. Int J Cancer. 2014 Nov 15;135(10):2262-72 - PubMed
  42. Blood. 2004 Feb 15;103(4):1237-43 - PubMed
  43. Haematologica. 1987 Mar-Apr;72(2):151-5 - PubMed
  44. Leukemia. 1994 Jun;8(6):968-73 - PubMed
  45. Br J Haematol. 1988 Mar;68(3):283-9 - PubMed
  46. Dev Biol. 1971 Aug;25(4):514-46 - PubMed
  47. Blood. 2010 Oct 28;116(17):3171-9 - PubMed
  48. Lancet. 1994 Apr 23;343(8904):1033 - PubMed
  49. Leukemia. 1996 Jan;10(1):61-6 - PubMed
  50. Blood. 2009 Jan 22;113(4):775-83 - PubMed
  51. Chin Med J (Engl). 1987 Dec;100(12):949-53 - PubMed
  52. Haematologica. 2020 Jun;105(6):1567-1574 - PubMed
  53. N Engl J Med. 1991 May 16;324(20):1385-93 - PubMed
  54. Leukemia. 2000 Aug;14(8):1371-7 - PubMed
  55. Cancer. 1985 Jan 1;55(1):18-25 - PubMed
  56. Best Pract Res Clin Haematol. 2014 Mar;27(1):3-9 - PubMed
  57. Leukemia. 1994;8 Suppl 2:S1-5 - PubMed
  58. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2694-8 - PubMed
  59. Blood. 1999 Aug 15;94(4):1192-200 - PubMed
  60. Am J Hematol. 1980;8(4):347-59 - PubMed
  61. Proc Natl Acad Sci U S A. 1971 Feb;68(2):378-82 - PubMed
  62. Blood. 1990 Jun 1;75(11):2112-7 - PubMed
  63. Blood. 1988 Aug;72(2):567-72 - PubMed
  64. Bone Marrow Transplant. 1994 Aug;14(2):293-8 - PubMed
  65. Leuk Lymphoma. 1991;4(4):249-56 - PubMed
  66. N Engl J Med. 1997 Oct 9;337(15):1021-8 - PubMed
  67. Schweiz Med Wochenschr. 1959 Jun 6;89:604-8 - PubMed
  68. Blood. 2008 Mar 1;111(5):2505-15 - PubMed
  69. Int J Cancer. 1977 Dec 15;20(6):869-72 - PubMed
  70. Oncogene. 2001 May 28;20(24):3110-5 - PubMed
  71. Nature. 1998 Feb 19;391(6669):815-8 - PubMed
  72. Br J Haematol. 2000 Mar;108(4):703-9 - PubMed
  73. Blood. 2009 Feb 26;113(9):1875-91 - PubMed
  74. J Clin Oncol. 1998 Jan;16(1):78-85 - PubMed
  75. Proc Natl Acad Sci U S A. 1980 May;77(5):2936-40 - PubMed
  76. Curr Oncol. 2014 Oct;21(5):234-50 - PubMed
  77. Br J Haematol. 1980 Jan;44(1):169-70 - PubMed
  78. Cell. 1997 May 2;89(3):373-80 - PubMed
  79. Blood. 1992 Jan 15;79(2):299-303 - PubMed
  80. J Clin Oncol. 1991 Sep;9(9):1556-61 - PubMed
  81. J Exp Med. 2004 Apr 19;199(8):1163-74 - PubMed
  82. Blood. 2010 Jun 24;115(25):5137-46 - PubMed
  83. Blood. 1987 Jan;69(1):187-91 - PubMed
  84. J Clin Oncol. 2001 Sep 15;19(18):3852-60 - PubMed
  85. Arch Intern Med. 1976 Jul;136(7):825-8 - PubMed
  86. Blood. 2006 Apr 1;107(7):2627-32 - PubMed
  87. Cell. 1991 Aug 23;66(4):675-84 - PubMed
  88. Am J Med. 1984 May;76(5):827-41 - PubMed
  89. J Exp Med. 1990 Dec 1;172(6):1571-5 - PubMed
  90. Blood. 1997 May 1;89(9):3345-53 - PubMed
  91. Cancer Genet Cytogenet. 1981 Apr;3(3):273-4 - PubMed
  92. Blood. 1981 Jun;57(6):1000-4 - PubMed
  93. Lancet. 1990 Dec 8;336(8728):1440-1 - PubMed
  94. Blood. 2006 May 1;107(9):3469-73 - PubMed
  95. Nat Genet. 1998 Feb;18(2):126-35 - PubMed
  96. Nature. 1978 Aug 10;274(5671):535-9 - PubMed
  97. Cell. 1991 Aug 23;66(4):663-74 - PubMed
  98. Blood. 1983 Dec;62(6):1211-7 - PubMed
  99. Cancer Cell. 2010 Feb 17;17(2):173-85 - PubMed
  100. Hum Genet. 1988 Oct;80(2):186-8 - PubMed
  101. Cell. 1999 Apr 2;97(1):5-8 - PubMed
  102. Cancer. 1961 Sep-Oct;14:1017-29 - PubMed
  103. Br J Haematol. 2003 Aug;122(4):539-53 - PubMed
  104. Blood. 1984 Jan;63(1):211-2 - PubMed
  105. Eur J Haematol. 1990 Apr;44(4):257-60 - PubMed
  106. Blood. 1990 Nov 1;76(9):1704-9 - PubMed
  107. Nat Cell Biol. 2008 May;10(5):547-55 - PubMed
  108. Blood. 1989 Apr;73(5):1116-22 - PubMed
  109. Zhonghua Xue Ye Xue Za Zhi. 2018 Mar 14;39(3):179-183 - PubMed
  110. Lancet Oncol. 2015 Oct;16(13):1295-305 - PubMed
  111. Nucleus. 2014;5(6):499-507 - PubMed
  112. Blood. 1995 Mar 1;85(5):1202-6 - PubMed
  113. Front Oncol. 2021 Mar 18;11:614215 - PubMed
  114. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14807-12 - PubMed
  115. Ann Intern Med. 1994 Feb 15;120(4):278-86 - PubMed
  116. Ann Oncol. 2006 Jan;17(1):131-4 - PubMed
  117. J Clin Oncol. 2013 Nov 20;31(33):4215-21 - PubMed
  118. Blood. 1973 Apr;41(4):489-96 - PubMed
  119. Acta Haematol. 1977;58(2):108-19 - PubMed
  120. Leukemia. 1994;8 Suppl 2:S48-55 - PubMed
  121. Nouv Rev Fr Hematol. 1990;32(1):34-6 - PubMed
  122. Cancer. 1988 Jan 1;61(1):7-13 - PubMed
  123. Nature. 1990 Oct 11;347(6293):558-61 - PubMed
  124. Mol Cell. 2000 May;5(5):821-30 - PubMed
  125. Leukemia. 1994 Jun;8(6):929-33 - PubMed

Publication Types