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Antioxidants (Basel). 2021 Dec 07;10(12). doi: 10.3390/antiox10121961.

Formation of Cyclobutane Pyrimidine Dimers after UVA Exposure (Dark-CPDs) Is Inhibited by an Hydrophilic Extract of .

Antioxidants (Basel, Switzerland)

Mikel Portillo-Esnaola, Azahara Rodríguez-Luna, Jimena Nicolás-Morala, María Gallego-Rentero, María Villalba, Ángeles Juarranz, Salvador González

Affiliations

  1. Department of Biology, Faculty of Sciences, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Autónoma University of Madrid (UAM), 28049 Madrid, Spain.
  2. Cantabria Labs, Innovation and Development, 28043 Madrid, Spain.
  3. Cantabria Labs, Medical Affairs Department, 28043 Madrid, Spain.
  4. Department of Medicine and Medical Specialties, Alcalá de Henares University, 28805 Madrid, Spain.

PMID: 34943064 DOI: 10.3390/antiox10121961

Abstract

Exposure to sun and especially to ultraviolet radiation (UVR) exerts well known detrimental effects on skin which are implicated in malignancy. UVR induces production of cyclobutane pyrimidine dimers (CPDs), immediately during exposure and even hours after the exposure, these latter being called dark-CPDs, as consequence of the effects of different reactive species that are formed. Fernblock

Keywords: Polypodium leucotomos; cyclobutane pyrimidine dimers; dark cyclobutene pyrimidine dimers; melanocytes; photoprotection; skin cancer; ultraviolet radiation

Publication Types

Grant support