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Shramko VS, Striukova EV, Polonskaya YV, et al. Associations of Antioxidant Enzymes with the Concentration of Fatty Acids in the Blood of Men with Coronary Artery Atherosclerosis. J Pers Med. 2021;11(12)doi: 10.3390/jpm11121281.
Shramko, V. S., Striukova, E. V., Polonskaya, Y. V., Stakhneva, E. M., Volkova, M. V., Kurguzov, A. V., Kashtanova, E. V., & Ragino, Y. I. (2021). Associations of Antioxidant Enzymes with the Concentration of Fatty Acids in the Blood of Men with Coronary Artery Atherosclerosis. Journal of personalized medicine, 11(12), . https://doi.org/10.3390/jpm11121281
Shramko, Viktoriya S, et al. "Associations of Antioxidant Enzymes with the Concentration of Fatty Acids in the Blood of Men with Coronary Artery Atherosclerosis." Journal of personalized medicine vol. 11,12 (2021). doi: https://doi.org/10.3390/jpm11121281
Shramko VS, Striukova EV, Polonskaya YV, Stakhneva EM, Volkova MV, Kurguzov AV, Kashtanova EV, Ragino YI. Associations of Antioxidant Enzymes with the Concentration of Fatty Acids in the Blood of Men with Coronary Artery Atherosclerosis. J Pers Med. 2021 Dec 02;11(12). doi: 10.3390/jpm11121281. PMID: 34945751.
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J Pers Med. 2021 Dec 02;11(12). doi: 10.3390/jpm11121281.

Associations of Antioxidant Enzymes with the Concentration of Fatty Acids in the Blood of Men with Coronary Artery Atherosclerosis.

Journal of personalized medicine

Viktoriya S Shramko, Eugeniia V Striukova, Yana V Polonskaya, Ekaterina M Stakhneva, Marina V Volkova, Alexey V Kurguzov, Elena V Kashtanova, Yuliya I Ragino

Affiliations

  1. Research Institute of Internal and Preventive Medicine, Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of IC&G SB RAS), 175/1 B. Bogatkova Str., 630089 Novosibirsk, Russia.
  2. Federal State Budgetary Institution "National Medical Research Center Named Academician E.N. Meshalkin", Ministry of Health of the Russian Federation, Rechkunovskaya Str., 15, 630055 Novosibirsk, Russia.

PMID: 34945751 DOI: 10.3390/jpm11121281

Abstract

OBJECTIVE: To identify associations of fatty acids (FAs) with the antioxidant enzymes in the blood of men with coronary atherosclerosis and ischemic heart disease (IHD).

METHODS: The study included 80 patients: control group-20 men without IHD, the core group-60 men with IHD. The core group was divided into subgroups: subgroup A-with the presence of vulnerable atherosclerotic plaques, subgroup B-with the absence of vulnerable atherosclerotic plaques. We analyzed the levels of FAs, free radicals, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in the blood.

RESULTS: Patients with IHD, compared with the control group: (1) had higher levels of SOD, CAT, myristic, palmitic, palmitoleic, and octadecenoic FAs; (2) had lower levels of GPx, α-linolenic, docosapentaenoic, docosahexaenoic, and arachidonic FAs. In subgroup A there were found: (1) negative associations of SOD-with linoleic, eicosatrienoic, arachidonic, eicosapentaenoic, docosapentaenoic and docosahexaenoic FAs, positive associations-with palmitic acid; (2) positive correlations of CAT level with palmitoleic and stearic acids; (3) negative associations between of GPx and palmitic, palmitoleic, stearic and octadecenoic FAs.

CONCLUSIONS: Changes in the levels of antioxidant enzymes, and a disbalance of the FAs profile, probably indicate active oxidative processes in the body and may indicate the presence of atherosclerotic changes in the vessels.

Keywords: catalase; coronary atherosclerosis; glutathione peroxidase; ischemic heart disease; monounsaturated fatty acids; oxidative stress; polyunsaturated fatty acids; saturated fatty acids; superoxide dismutase

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