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Oca AI, Pérez-Sala Á, Pariente A, et al. Predictive Biomarkers of Age-Related Macular Degeneration Response to Anti-VEGF Treatment. J Pers Med. 2021;11(12)doi: 10.3390/jpm11121329.
Oca, A. I., Pérez-Sala, �. �., Pariente, A., Ochoa, R., Velilla, S., Peláez, R., & Larráyoz, I. M. (2021). Predictive Biomarkers of Age-Related Macular Degeneration Response to Anti-VEGF Treatment. Journal of personalized medicine, 11(12), . https://doi.org/10.3390/jpm11121329
Oca, Ana I, et al. "Predictive Biomarkers of Age-Related Macular Degeneration Response to Anti-VEGF Treatment." Journal of personalized medicine vol. 11,12 (2021). doi: https://doi.org/10.3390/jpm11121329
Oca AI, Pérez-Sala Á, Pariente A, Ochoa R, Velilla S, Peláez R, Larráyoz IM. Predictive Biomarkers of Age-Related Macular Degeneration Response to Anti-VEGF Treatment. J Pers Med. 2021 Dec 08;11(12). doi: 10.3390/jpm11121329. PMID: 34945801.
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J Pers Med. 2021 Dec 08;11(12). doi: 10.3390/jpm11121329.

Predictive Biomarkers of Age-Related Macular Degeneration Response to Anti-VEGF Treatment.

Journal of personalized medicine

Ana I Oca, Álvaro Pérez-Sala, Ana Pariente, Rodrigo Ochoa, Sara Velilla, Rafael Peláez, Ignacio M Larráyoz

Affiliations

  1. Biomarkers and Molecular Signaling Group, Center for Biomedical Research of La Rioja (CIBIR), Foundation Rioja Salud, 26006 Logroño, La Rioja, Spain.
  2. Unidad Predepartamental de Enfermería, Universidad de La Rioja (UR), 26006 Logroño, La Rioja, Spain.

PMID: 34945801 DOI: 10.3390/jpm11121329

Abstract

Age-related macular degeneration (AMD) is an incurable disease associated with aging that destroys sharp and central vision. Increasing evidence implicates both systemic and local inflammation in the pathogenesis of AMD. Intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents is currently the first-line therapy for choroidal neovascularization in AMD patients. However, a high number of patients do not show satisfactory responses to anti-VEGF treatment after three injections. Predictive treatment response models are one of the most powerful tools for personalized medicine. Therefore, the application of these models is very helpful to predict the optimal treatment for an early application on each patient. We analyzed the transcriptome of peripheral blood mononuclear cells (PBMCs) from AMD patients before treatment to identify biomarkers of response to ranibizumab. A classification model comprised of four mRNAs and one miRNA isolated from PBMCs was able to predict the response to ranibizumab with high accuracy (Area Under the Curve of the Receiver Operating Characteristic curve = 0.968), before treatment. We consider that our classification model, based on mRNA and miRNA from PBMCs allows a robust prediction of patients with insufficient response to anti-VEGF treatment. In addition, it could be used in combination with other methods, such as specific baseline characteristics, to identify patients with poor response to anti-VEGF treatment to establish patient-specific treatment plans at the first visit.

Keywords: PBMC; RNA-Seq; machine learning; ranibizumab; retina

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