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Kukushkin M, Novotortsev V, Filatov V, et al. Synthesis and Biological Evaluation of S-, O- and Se-Containing Dispirooxindoles. Molecules. 2021;26(24)doi: 10.3390/molecules26247645.
Kukushkin, M., Novotortsev, V., Filatov, V., Ivanenkov, Y., Skvortsov, D., Veselov, M., Shafikov, R., Moiseeva, A., Zyk, N., Majouga, A., & Beloglazkina, E. (2021). Synthesis and Biological Evaluation of S-, O- and Se-Containing Dispirooxindoles. Molecules (Basel, Switzerland), 26(24), . https://doi.org/10.3390/molecules26247645
Kukushkin, Maksim, et al. "Synthesis and Biological Evaluation of S-, O- and Se-Containing Dispirooxindoles." Molecules (Basel, Switzerland) vol. 26,24 (2021). doi: https://doi.org/10.3390/molecules26247645
Kukushkin M, Novotortsev V, Filatov V, Ivanenkov Y, Skvortsov D, Veselov M, Shafikov R, Moiseeva A, Zyk N, Majouga A, Beloglazkina E. Synthesis and Biological Evaluation of S-, O- and Se-Containing Dispirooxindoles. Molecules. 2021 Dec 16;26(24). doi: 10.3390/molecules26247645. PMID: 34946727.
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Molecules. 2021 Dec 16;26(24). doi: 10.3390/molecules26247645.

Synthesis and Biological Evaluation of S-, O- and Se-Containing Dispirooxindoles.

Molecules (Basel, Switzerland)

Maksim Kukushkin, Vladimir Novotortsev, Vadim Filatov, Yan Ivanenkov, Dmitry Skvortsov, Mark Veselov, Radik Shafikov, Anna Moiseeva, Nikolay Zyk, Alexander Majouga, Elena Beloglazkina

Affiliations

  1. Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, GSP-1, 119991 Moscow, Russia.
  2. Research Laboratory of Biophysics, National University of Science and Technology MISiS, 119049 Moscow, Russia.
  3. Laboratory of Medicinal Chemistry and Bioinformatic, Moscow Institute of Physics and Technology (MIPT), Institutski Pereulok 9, 141701 Dolgoprudny, Russia.
  4. Dmitry Mendeleev University of Chemical Technology of Russia, Miusskaya Sq. 9, 125047 Moscow, Russia.

PMID: 34946727 DOI: 10.3390/molecules26247645

Abstract

A series of novel S-, O- and Se-containing dispirooxindole derivatives has been synthesized using 1,3-dipolar cycloaddition reaction of azomethine ylide generated from isatines and sarcosine at the double C=C bond of 5-indolidene-2-chalcogen-imidazolones (chalcogen was oxygen, sulfur or selenium). The cytotoxicity of these dispiro derivatives was evaluated in vitro using different tumor cell lines. Several molecules have demonstrated a considerable cytotoxicity against the panel and showed good selectivity towards colorectal carcinoma HCT116 p53

Keywords: 3D molecular docking; anticancer activity; cytotoxicity; dispirooxindoles; p53/MDM2 interaction

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Grant support