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Shintouo CM, Ghogomu SM, Shey RA, et al. Tandem Use of OvMANE1 and Ov-16 ELISA Tests Increases the Sensitivity for the Diagnosis of Human Onchocerciasis. Life (Basel). 2021;11(12)doi: 10.3390/life11121284.
Shintouo, C. M., Ghogomu, S. M., Shey, R. A., Hotterbeekx, A., Yagmur, E., Mets, T., Vanhamme, L., Colebunders, R., Souopgui, J., & Njemini, R. (2021). Tandem Use of OvMANE1 and Ov-16 ELISA Tests Increases the Sensitivity for the Diagnosis of Human Onchocerciasis. Life (Basel, Switzerland), 11(12), . https://doi.org/10.3390/life11121284
Shintouo, Cabirou Mounchili, et al. "Tandem Use of OvMANE1 and Ov-16 ELISA Tests Increases the Sensitivity for the Diagnosis of Human Onchocerciasis." Life (Basel, Switzerland) vol. 11,12 (2021). doi: https://doi.org/10.3390/life11121284
Shintouo CM, Ghogomu SM, Shey RA, Hotterbeekx A, Yagmur E, Mets T, Vanhamme L, Colebunders R, Souopgui J, Njemini R. Tandem Use of OvMANE1 and Ov-16 ELISA Tests Increases the Sensitivity for the Diagnosis of Human Onchocerciasis. Life (Basel). 2021 Nov 23;11(12). doi: 10.3390/life11121284. PMID: 34947815.
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Life (Basel). 2021 Nov 23;11(12). doi: 10.3390/life11121284.

Tandem Use of OvMANE1 and Ov-16 ELISA Tests Increases the Sensitivity for the Diagnosis of Human Onchocerciasis.

Life (Basel, Switzerland)

Cabirou Mounchili Shintouo, Stephen Mbigha Ghogomu, Robert Adamu Shey, An Hotterbeekx, Emel Yagmur, Tony Mets, Luc Vanhamme, Robert Colebunders, Jacob Souopgui, Rose Njemini

Affiliations

  1. Department of Gerontology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
  2. Frailty in Ageing Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
  3. Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea P.O Box 63, Cameroon.
  4. Global Health Institute, University of Antwerp, 2610 Antwerp, Belgium.
  5. Department of Molecular Biology, Institute of Biology and Molecular Medicine, IBMM, Gosselies Campus, Université Libre de Bruxelles, 126040 Gosselies, Belgium.
  6. Department of Geriatric Medicine, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.

PMID: 34947815 DOI: 10.3390/life11121284

Abstract

The current serological test for human onchocerciasis relies on IgG4 reactivity against the parasite Ov-16 antigen, with reported sensitivities of only 60-80%. As control programs move from control to elimination, it is imperative to identify novel molecules that could improve the serodiagnosis reliability of this disease. In this study we compared the sensitivity of total IgG against OvMANE1-a chimeric antigen previously identified as a potential biomarker of human onchocerciasis-with that of an Ov-16 antibody test to detect an

Keywords: ELISA; Onchocerca volvulus; Ov-16; OvMANE1; antibodies; diagnostic; sensitivity

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