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Damanaki A, Memmert S, Nokhbehsaim M, et al. Effects of Obesity on Bone Healing in Rats. Int J Mol Sci. 2021;22(24)doi: 10.3390/ijms222413339.
Damanaki, A., Memmert, S., Nokhbehsaim, M., Abedi, A., Rath-Deschner, B., Nogueira, A., & Deschner, J. (2021). Effects of Obesity on Bone Healing in Rats. International journal of molecular sciences, 22(24), . https://doi.org/10.3390/ijms222413339
Damanaki, Anna, et al. "Effects of Obesity on Bone Healing in Rats." International journal of molecular sciences vol. 22,24 (2021). doi: https://doi.org/10.3390/ijms222413339
Damanaki A, Memmert S, Nokhbehsaim M, Abedi A, Rath-Deschner B, Nogueira A, Deschner J. Effects of Obesity on Bone Healing in Rats. Int J Mol Sci. 2021 Dec 11;22(24). doi: 10.3390/ijms222413339. PMID: 34948136.
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Int J Mol Sci. 2021 Dec 11;22(24). doi: 10.3390/ijms222413339.

Effects of Obesity on Bone Healing in Rats.

International journal of molecular sciences

Anna Damanaki, Svenja Memmert, Marjan Nokhbehsaim, Ali Abedi, Birgit Rath-Deschner, Andressa Nogueira, James Deschner

Affiliations

  1. Department of Periodontology and Operative Dentistry, University Medical Center, University of Mainz, 55131 Mainz, Germany.
  2. Center of Dento-Maxillo-Facial Medicine, Department of Orthodontics, University of Bonn, 53111 Bonn, Germany.
  3. Section of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany.

PMID: 34948136 DOI: 10.3390/ijms222413339

Abstract

Although the association between periodontitis and obesity is well explored, it is unclear whether obesity is associated with a worse therapeutic outcome after periodontal treatment. The aim of this study was to investigate the effects of obesity on bone healing with and without the application of regeneration-promoting molecules. A standardized bone fenestration-type defect was created over the root of the mandibular first molar in 15 Wistar rats. Ten animals received a high-fat, high-sucrose diet (HFSD), while the remaining five animals were fed a standard diet. During surgery, the fenestration defects from half of the HFSD-fed, i.e., obese animals, were treated with regeneration-promoting molecules (enamel matrix derivative; EMD). After four weeks, bone healing was evaluated by histomorphometry, TRAP staining and immunohistochemistry for RUNX2 and osteopontin. The analyses revealed that the spontaneous healing of the periodontal defects was compromised by obesity. Application of EMD partially compensated for the negative effect of obesity. Nevertheless, EMD-stimulated bone healing in obese animals was not better than the spontaneous healing in the obesity-free control group, indicating that obesity may also inhibit the stimulatory effects of regeneration-promoting molecules. Our results show that obesity can negatively influence bone healing and suggest that bone healing may be compromised in humans.

Keywords: animal; fenestration; obesity; periodontal regeneration; periodontitis

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Grant support