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Sobolev VE, Sokolova MO, Jenkins RO, et al. Nephrotoxic Effects of Paraoxon in Three Rat Models of Acute Intoxication. Int J Mol Sci. 2021;22(24)doi: 10.3390/ijms222413625.
Sobolev, V. E., Sokolova, M. O., Jenkins, R. O., & Goncharov, N. V. (2021). Nephrotoxic Effects of Paraoxon in Three Rat Models of Acute Intoxication. International journal of molecular sciences, 22(24), . https://doi.org/10.3390/ijms222413625
Sobolev, Vladislav E, et al. "Nephrotoxic Effects of Paraoxon in Three Rat Models of Acute Intoxication." International journal of molecular sciences vol. 22,24 (2021). doi: https://doi.org/10.3390/ijms222413625
Sobolev VE, Sokolova MO, Jenkins RO, Goncharov NV. Nephrotoxic Effects of Paraoxon in Three Rat Models of Acute Intoxication. Int J Mol Sci. 2021 Dec 20;22(24). doi: 10.3390/ijms222413625. PMID: 34948422.
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Int J Mol Sci. 2021 Dec 20;22(24). doi: 10.3390/ijms222413625.

Nephrotoxic Effects of Paraoxon in Three Rat Models of Acute Intoxication.

International journal of molecular sciences

Vladislav E Sobolev, Margarita O Sokolova, Richard O Jenkins, Nikolay V Goncharov

Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Thorez 44, 194223 St. Petersburg, Russia.
  2. Leicester School of Allied Health Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK.

PMID: 34948422 DOI: 10.3390/ijms222413625

Abstract

The delayed effects of acute intoxication by organophosphates (OPs) are poorly understood, and the various experimental animal models often do not take into account species characteristics. The principal biochemical feature of rodents is the presence of carboxylesterase in blood plasma, which is a target for OPs and can greatly distort their specific effects. The present study was designed to investigate the nephrotoxic effects of paraoxon (O,O-diethyl O-(4-nitrophenyl) phosphate, POX) using three models of acute poisoning in outbred Wistar rats. In the first model (

Keywords: biomarkers; calbindin; chondroitin sulphate; creatinine clearance; electron microscopy; glycosaminoglycans; histopathology; morphometry; nephrin; nephrotoxicity; paraoxon; rats

Publication Types

Grant support