Gynecol Obstet Fertil Senol. 2021 Dec 23; doi: 10.1016/j.gofs.2021.12.008. Epub 2021 Dec 23.
Gynecologie, obstetrique, fertilite & senologie
[Article in French] Catherine Vauzelle
PMID: 34954405 DOI: 10.1016/j.gofs.2021.12.008
In 2001 a clinical trial on prophylactic antibiotics in preterm prelabor rupture of membranes reported an increased risk of necrotizing enterocolitis in newborns whose mothers were given amoxicillin-clavulanic acid before delivery. This study generated concern and reluctance to use this antibiotic in late pregnancy, despite its methodological limitations and the lack of confirmation in 3 studies published between 2001 and 2008. Since then, there have been no original publications on the topic. Therefore, the results available to date do not support an increased risk of necrotizing colitis with the use of amoxicillin-clavulanic acid in late pregnancy. In clinical situations where amoxicillin/clavulanic acid is required, it can be prescribed at any stage of pregnancy, including just before delivery.
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Keywords: Augmentin®; acide clavulanique; clavulanic acid; entérocolite ulcéro-nécrosante; grossesse; necrotizing enterocolitis; newborn; nouveau-né; pregnancy