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Sobh M, Freitag-Wolf S, Scheewe J, et al. Serial right ventricular assessment in patients with hypoplastic left heart syndrome: a multiparametric cardiovascular magnetic resonance study. Eur J Cardiothorac Surg. 2021;61(1):36-42doi: 10.1093/ejcts/ezab232.
Sobh, M., Freitag-Wolf, S., Scheewe, J., Kanngiesser, L. M., Uebing, A. S., Gabbert, D. D., & Voges, I. (2021). Serial right ventricular assessment in patients with hypoplastic left heart syndrome: a multiparametric cardiovascular magnetic resonance study. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 61(1), 36-42. https://doi.org/10.1093/ejcts/ezab232
Sobh, Mohamed, et al. "Serial right ventricular assessment in patients with hypoplastic left heart syndrome: a multiparametric cardiovascular magnetic resonance study." European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery vol. 61,1 (2021): 36-42. doi: https://doi.org/10.1093/ejcts/ezab232
Sobh M, Freitag-Wolf S, Scheewe J, Kanngiesser LM, Uebing AS, Gabbert DD, Voges I. Serial right ventricular assessment in patients with hypoplastic left heart syndrome: a multiparametric cardiovascular magnetic resonance study. Eur J Cardiothorac Surg. 2021 Dec 27;61(1):36-42. doi: 10.1093/ejcts/ezab232. PMID: 34050651.
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Eur J Cardiothorac Surg. 2021 Dec 27;61(1):36-42. doi: 10.1093/ejcts/ezab232.

Serial right ventricular assessment in patients with hypoplastic left heart syndrome: a multiparametric cardiovascular magnetic resonance study.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

Mohamed Sobh, Sandra Freitag-Wolf, Jens Scheewe, Luca M Kanngiesser, Anselm S Uebing, Dominik D Gabbert, Inga Voges

Affiliations

  1. Department of Congenital Heart Disease and Paediatric Cardiology, University Hospital Schleswig-Holstein, Kiel, Germany.
  2. Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.
  3. Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein, Kiel, Germany.

PMID: 34050651 DOI: 10.1093/ejcts/ezab232

Abstract

OBJECTIVES: The aim of this study was to assess single right ventricular (RV) function in a large cohort of hypoplastic left heart syndrome (HLHS) patients after the completion of total cavopulmonary connection by analysing serial cardiovascular magnetic resonance (CMR) studies.

METHODS: CMR studies from 95 HLHS patients were analysed. RV end-diastolic and end-systolic volumes (RVEDV, RVESV), ejection fraction (RVEF) and long-axis strain (LAS) were measured from cine images.

RESULTS: All 95 patients had at least 2 CMR scans and 35 patients had 3 CMR scans. The median age (first quartile-third quartile) at the 3 examinations was 4.2 (3.3-6.1), 9.4 (6.1-11.4) and 14.6 (11.8-16.8) years. RV indexed volumes (RVEDVi and RVESVi) increased from first to the second and from the first and second examination to the third examination in patients with >10 years of age (P < 0.05). There was a slight decrease in RVEF and LAS throughout the examinations, but this was not statistically significant. Correlations were found between RVEF and LAS (r = -0.23; P < 0.01). Both RVEF and LAS correlated with RVEDVi and RVESVi (r = -0.17 to 0.43; P < 0.05).

CONCLUSIONS: Serial assessment of CMR studies in HLHS patients after total cavopulmonary connection completion demonstrate an increase in indexed RV volumes in older HLHS patients but only mild reduction in RVEF and LAS. The correlation of indexed RV volumes with RVEF and LAS together with the significant increase in RV volumes over time suggests that indexed RV volumes might be superior to RV functional markers to monitor the RV in HLHS patients.

© The Author(s) 2021. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Keywords: Cardiovascular magnetic resonance imaging; Fontan circulation; Hypoplastic left heart syndrome; Univentricular hearts

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