Mol Biol. 2021;55(6):773-785. doi: 10.1134/S0026893321050113. Epub 2021 Dec 17.

Plasmolipin and Its Role in Cell Processes.

Molecular biology

A A Shulgin, T D Lebedev, V S Prassolov, P V Spirin

PMID: 34955555 PMCID: PMC8682038 DOI: 10.1134/S0026893321050113

Abstract

The mechanisms involved in the origin and development of malignant and neurodegenerative diseases are an important area of modern biomedicine. A crucial task is to identify new molecular markers that are associated with rearrangements of intracellular signaling and can be used for prognosis and the development of effective treatment approaches. The proteolipid plasmolipin (PLLP) is a possible marker. PLLP is a main component of the myelin sheath and plays an important role in the development and normal function of the nervous system. PLLP is involved in intracellular transport, lipid raft formation, and Notch signaling. PLLP is presumably involved in various disorders, such as cancer, schizophrenia, Alzheimer's disease, and type 2 diabetes mellitus. PLLP and its homologs were identified as possible virus entry receptors. The review summarizes the data on the PLLP structure, normal functions, and role in diseases.

© The Author(s) 2021, ISSN 0026-8933, Molecular Biology, 2021, Vol. 55, No. 6, pp. 773–785. © The Author(s), 2021. This article is an open access publication.Russian Text © The Author(s), 2021, published in Molekulyarnaya Biologiya, 2021, Vol. 55, No. 6, pp. 883–896.

Keywords: MARVEL; Notch signaling; SNARE; intracellular transport; ion channels; lipid rafts; neurodegenerative disorders; proteolipids

Conflict of interest statement

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• Journal Article