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Fettach S, Thari FZ, Hafidi Z, et al. Biological, toxicological and molecular docking evaluations of isoxazoline-thiazolidine-2,4-dione analogues as new class of anti-hyperglycemic agents. J Biomol Struct Dyn. 2021;1-13doi: 10.1080/07391102.2021.2017348.
Fettach, S., Thari, F. Z., Hafidi, Z., Karrouchi, K., Bouathmany, K., Cherrah, Y., El Achouri, M., Benbacer, L., El Mzibri, M., Sefrioui, H., Bougrin, K., & Faouzi, M. E. A. (2021). Biological, toxicological and molecular docking evaluations of isoxazoline-thiazolidine-2,4-dione analogues as new class of anti-hyperglycemic agents. Journal of biomolecular structure & dynamics, 1-13. https://doi.org/10.1080/07391102.2021.2017348
Fettach, Saad, et al. "Biological, toxicological and molecular docking evaluations of isoxazoline-thiazolidine-2,4-dione analogues as new class of anti-hyperglycemic agents." Journal of biomolecular structure & dynamics vol. (2021): 1-13. doi: https://doi.org/10.1080/07391102.2021.2017348
Fettach S, Thari FZ, Hafidi Z, Karrouchi K, Bouathmany K, Cherrah Y, El Achouri M, Benbacer L, El Mzibri M, Sefrioui H, Bougrin K, Faouzi MEA. Biological, toxicological and molecular docking evaluations of isoxazoline-thiazolidine-2,4-dione analogues as new class of anti-hyperglycemic agents. J Biomol Struct Dyn. 2021 Dec 26;1-13. doi: 10.1080/07391102.2021.2017348. Epub 2021 Dec 26. PMID: 34957934.
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J Biomol Struct Dyn. 2021 Dec 26;1-13. doi: 10.1080/07391102.2021.2017348. Epub 2021 Dec 26.

Biological, toxicological and molecular docking evaluations of isoxazoline-thiazolidine-2,4-dione analogues as new class of anti-hyperglycemic agents.

Journal of biomolecular structure & dynamics

Saad Fettach, Fatima Zahra Thari, Zakaria Hafidi, Khalid Karrouchi, Kaoutar Bouathmany, Yahia Cherrah, Mohammed El Achouri, Laila Benbacer, Mohammed El Mzibri, Hassan Sefrioui, Khalid Bougrin, My El Abbes Faouzi

Affiliations

  1. Laboratory of Pharmacology and Toxicology, Biopharmaceutical and Toxicological Analysis Research Team, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat, Morocco.
  2. Equipe de Chimie des Plantes et de Synthèse Organique et Bioorganique, URAC23, Faculty of Science, B.P. 1014, Geophysics, Natural Patrimony and Green Chemistry (GEOPAC) Research Center, Mohammed V University in Rabat, Rabat, Morocco.
  3. Department of Surfactants and Nanobiotechnology, IQAC-CSIC, c/Jordi Girona, Barcelona, Spain.
  4. Laboratory of Analytical Chemistry and Bromatology, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat, Morocco.
  5. Biology and Molecular Research Unit, Department of Life Sciences, National Center for Energy, Nuclear Science and Technology (CNESTEN), Rabat, Morocco.
  6. Laboratoire de Physico-Chimie des Matériaux Inorganiques et Organiques, Centre des Sciences des Matériaux, Ecole Normale Supérieure-Rabat, Mohammed V University, Rabat, Morocco.
  7. Moroccan Foundation for Science, Innovation & Research (MAScIR), Centre de Biotechnologie Médicale, Rabat, Morocco.
  8. Chemical and Biochemical Sciences Green Process Engineering (CBS), Mohammed VI Polytechnic University (UM6P), Benguerir, Morocco.

PMID: 34957934 DOI: 10.1080/07391102.2021.2017348

Abstract

In this work, three isoxazoline-thiazolidine-2,4-dione derivatives were synthesized and characterized by FT-IR,

Keywords: SAR; Thiazolidine-2,4-dione; antihyperglycemic potential; isoxazoline; toxicity analysis; α-amylase inhibition; α-glucosidase inhibition

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